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Recent advances in chloroplast and mitochondrial division

Niven, Keith P., Kiefel, Ben R. and Beech, Peter 2007, Recent advances in chloroplast and mitochondrial division, Dynamic cell biology, vol. 1, no. 1, pp. 34-41.

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Title Recent advances in chloroplast and mitochondrial division
Author(s) Niven, Keith P.
Kiefel, Ben R.
Beech, Peter
Journal name Dynamic cell biology
Volume number 1
Issue number 1
Start page 34
End page 41
Publisher Global Science Books
Place of publication Isleworth, England
Publication date 2007
ISSN 1749-0561
Summary Stomatin, originally identified as a major protein of the human erythrocyte membrane, is widely expressed in various tissues. Orthologues are found in vertebrates, invertebrates, plants, and microorganisms. Related proteins exhibit a common core structure, termed the prohibitin (PHB) domain, with varying extensions. Stomatin has an unusual topology, similar to caveolin-1, with a hydrophobic domain embedded at the cytoplasmic side of the membrane. Additional anchoring is provided by palmitoylation and the membrane affinity of the PHB domain. Stomatin associates with cholesterol-rich microdomains (lipid rafts), forms oligomers, and thereby displays a scaffolding function by generating large protein-lipid complexes. It regulates the activity of various membrane proteins by reversibly recruiting them to lipid rafts. This mechanism of regulation has been shown for GLUT-1 and may also apply for ion channels. Stomatin is located at the plasma membrane, particularly in microvilli, in endocytic and exocytic vesicles, and cytoplasmic granules. Stomatin-carrying endosomes are highly dynamic and interact with lipid droplets suggesting a role in intracellular lipid transport. This subcellular distribution and the caveolin-like protein structure suggest important membrane organizing functions for stomatin. A general picture emerges now that cell membranes contain cholesterol-rich domains that are generated and regulated by scaffolding proteins like caveolins, stomatins, and flotillin/reggie proteins.
Language eng
Field of Research 060409 Molecular Evolution
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2005-2008, Global Science Books
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Document type: Journal Article
Collections: School of Life and Environmental Sciences
Institute of Biotechnology
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