Stringer-stiffened plate-like structure is a typical engineering structure and its structural integrity is critical. A guided Lamb wave-based damage identification scheme and an online structural health monitoring (SHM) system with an integrated PZT-sensor network were developed. In the previous studies, the specimens were relatively simple. In this paper, the above mentioned method was extended to the stiffened plate-like structure—a flat plate reinforced by stringer. FE dynamic simulation was applied to investigate the Lamb wave propagation characteristics due to the existence of stringer with the consideration of its material and geometric configurations.