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Sulfatide-tenascin interaction mediates binding to the extracellular matrix and endocytic uptake of liposomes in glioma cells

Shao, K., Hou, Q., Go, M., Duan, Wei, Cheung, N., Feng, S., Wong, K., Yoram, A., Zhang, W., Huang, Z. and Li, Q. 2007, Sulfatide-tenascin interaction mediates binding to the extracellular matrix and endocytic uptake of liposomes in glioma cells, Cellular and molecular life sciences, vol. 64, no. 4, pp. 506-515.

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Title Sulfatide-tenascin interaction mediates binding to the extracellular matrix and endocytic uptake of liposomes in glioma cells
Author(s) Shao, K.
Hou, Q.
Go, M.
Duan, Wei
Cheung, N.
Feng, S.
Wong, K.
Yoram, A.
Zhang, W.
Huang, Z.
Li, Q.
Journal name Cellular and molecular life sciences
Volume number 64
Issue number 4
Start page 506
End page 515
Publisher Birkhaeuser Verlag
Place of publication Basel, Switzerland
Publication date 2007-02
ISSN 1420-682X
1420-9071
Keyword(s) ligand-targeted drug delivery
liposomes
sulfatide
tenascin-C
extracellular matrix
Summary Tenascin-C is an extracellular matrix glycoprotein, whose expression is highly restricted in normal adult tissues, but markedly up-regulated in a range of tumors, and therefore serves as a potential receptor for targeted anticancer drug or gene delivery. We describe here a liposomal carrier system in which the targeting ligand is sulfatide. Experiments with tenascin-C-expressing glioma cells demonstrated that binding of liposomes to the extracellular matrix relied essentially on the sulfatide-tenascin-C interaction. Following binding to the extracellular matrix, the sulfatide-containing liposomes were internalized via both caveolae/lipid raft- and clathrin-dependent pathways, which would ensure direct cytoplasmic release of the cargoes carried in the liposomes. Such natural lipid-guided intracellular delivery targeting at the extracellular matrix glycoproteins of tumor cells thus opens a new direction for development of more effective anticancer chemotherapeutics in future.
Language eng
Field of Research 110104 Medical Biochemistry: Lipids
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2007, Birkhaeuser Verlag, Basel
Persistent URL http://hdl.handle.net/10536/DRO/DU:30007432

Document type: Journal Article
Collection: School of Medicine
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