Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats

Yu, Xi-Yong, Lin, Shu-Guang, Zhou, Zhi-Wei, Chen, Xiao, Liang, Jun, Duan, Wei, Yu, Xue-Qing, Wen, Jing-Yuan, Chowbay, Balram, Li, Chun-Guang, Sheu, Fwu-Shan, Chan, Eli and Zhou, Shu-Feng 2007, Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats, Neuroscience letters, vol. 417, no. 3, pp. 261-265.

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Title Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats
Formatted title Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats
Author(s) Yu, Xi-Yong
Lin, Shu-Guang
Zhou, Zhi-Wei
Chen, Xiao
Liang, Jun
Duan, Wei
Yu, Xue-Qing
Wen, Jing-Yuan
Chowbay, Balram
Li, Chun-Guang
Sheu, Fwu-Shan
Chan, Eli
Zhou, Shu-Feng
Journal name Neuroscience letters
Volume number 417
Issue number 3
Start page 261
End page 265
Publisher Elsevier Ireland Ltd
Place of publication Limerick, Ireland
Publication date 2007-05-07
ISSN 0304-3940
1872-7972
Keyword(s) stroke
Tanshinone IIB
focal infarct
middle cerebral artery occlusion
rat
Summary Tanshinone IIB (TSB) is a major active constituent of the root of Salvia miltiorrhiza (Danshen) used in the treatment of acute stroke. Danshen extracts and TSB have shown marked neuron-protective effects in mouse studies but there is a lack of clinical evidence for the neuron-protective effects of Danshen and its active ingredients. This study investigated the neuron-protective effects of TSB in experimentally stroked rats. TSB at 5 and 25 mg/kg by intraperitoneal injection significantly reduced the focal infarct volume, cerebral histological damage and apoptosis in rats subjected to middle cerebral artery occlusion (MCAO) compared to MCAO rats receiving vehicle. This study demonstrated that TSB was effective in reducing stroke-induced brain damage and may represent a novel drug candidate for further development. Further mechanistic studies are needed for the neuron-protective activity of TSB.
Language eng
Field of Research 110404 Traditional Chinese Medicine and Treatments
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2007, Elsevier Ireland Ltd
Persistent URL http://hdl.handle.net/10536/DRO/DU:30007439

Document type: Journal Article
Collection: School of Medicine
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