Rapid determination of papaver somniferum alkaloids in process streams using monolithic column high-performance liquid chromatography with chemiluminescence detection

Costin, Jason, Lewis, Simon, Purcell, Stuart D., Waddell, Lucy, Francis, Paul and Barnett, Neil 2007, Rapid determination of papaver somniferum alkaloids in process streams using monolithic column high-performance liquid chromatography with chemiluminescence detection, Analytica chimica acta, vol. 597, no. 1, pp. 19-23.

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Title Rapid determination of papaver somniferum alkaloids in process streams using monolithic column high-performance liquid chromatography with chemiluminescence detection
Formatted title Rapid determination of Papaver somniferum alkaloids in process streams using monolithic column high-performance liquid chromatography with chemiluminescence detection
Author(s) Costin, Jason
Lewis, Simon
Purcell, Stuart D.
Waddell, Lucy
Francis, Paul
Barnett, Neil
Journal name Analytica chimica acta
Volume number 597
Issue number 1
Start page 19
End page 23
Publisher Elsevier BV
Place of publication Amsterdam, Netherlands
Publication date 2007-07-30
ISSN 0003-2670
1873-4324
0924-2031
Keyword(s) monolithic column
alkaloids
chemiluminescence
Summary We have combined high-performance liquid chromatography (HPLC) separations using a monolithic column with acidic potassium permanganate and tris(2,2′-bipyridyl)ruthenium(II) chemiluminescence detection in a rapid and highly sensitive method to monitor the process of extracting opiate alkaloids from Papaver somniferum. Due to the high flow rates allowed with the monolithic column and the inherent selectivity of the chemiluminescence reactions, the four predominant alkaloids – morphine, codeine, oripavine and thebaine – were determined in less than 2 min. The results obtained with numerous process samples compared favourable with those of the standard HPLC methodology. Limits of detection were 1 × 10−10 M, 5 × 10−10 M, 5 × 10−10 M and 1 × 10−9 M, for morphine, codeine, oripavine and thebaine, respectively.
Notes Available online 27 June 2007.
Language eng
Field of Research 030108 Separation Science
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2007, Elsevier B.V.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30007489

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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