Determination of opiate alkaloids in process liquors using capillary electrophoresis

Hindson, Benjamin, Francis, Paul, Purcell, Stuart D. and Barnett, Neil 2007, Determination of opiate alkaloids in process liquors using capillary electrophoresis, Journal of pharmaceutical and biomedical analysis, vol. 43, no. 3, pp. 1164-1168, doi: 10.1016/j.jpba.2006.09.040.

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Title Determination of opiate alkaloids in process liquors using capillary electrophoresis
Author(s) Hindson, Benjamin
Francis, PaulORCID iD for Francis, Paul
Purcell, Stuart D.
Barnett, Neil
Journal name Journal of pharmaceutical and biomedical analysis
Volume number 43
Issue number 3
Start page 1164
End page 1168
Publisher Elsevier
Place of publication New York, NY.
Publication date 2007-02-19
ISSN 0731-7085
Keyword(s) papaver somniferum alkaloids
Summary This paper describes the determination of opiate alkaloids (morphine, codeine, oripavine and thebaine) in industrial process liquors using capillary zone electrophoresis with UV-absorption detection at 214 nm. A study of cyclodextrin type and concentration revealed that the addition of 30 mM hydroxypropyl-β-cyclodextrin to the electrolyte solution (100 mM Tris adjusted to pH 2.8) was suitable to resolve the four analytes of interest. Typical analysis time was 12 min and the limit of detection for each alkaloid was 2.5 × 10−6 M. The results for the proposed methodology were in good agreement with those of a conventional HPLC procedure. Under the same conditions, short-end injection was used to reduce the effective separation length from 41.5 to 8.5 cm, which allowed the determination of morphine and thebaine in process liquors within 2.5 min.

Language eng
DOI 10.1016/j.jpba.2006.09.040
Field of Research 030108 Separation Science
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2006, Elsevier B.V.
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