Conversion of urea to hydrazine: Hofmann reaction or Favorskii analogue? Exploring reaction mechanism through isotopic labeling studies

Francis, Paul and Lim, Kieran 2007, Conversion of urea to hydrazine: Hofmann reaction or Favorskii analogue? Exploring reaction mechanism through isotopic labeling studies, Chemical educator, vol. 12, no. 5, pp. 307-313.


Title Conversion of urea to hydrazine: Hofmann reaction or Favorskii analogue? Exploring reaction mechanism through isotopic labeling studies
Author(s) Francis, Paul
Lim, Kieran
Journal name Chemical educator
Volume number 12
Issue number 5
Start page 307
End page 313
Publisher Boise State University
Place of publication Boise, Ind.
Publication date 2007-10
ISSN 1430-4171
Keyword(s) in the classroom
organic chemistry
physical chemistry
isotopes
kinetics
mechanisms of reactions
Summary The power of isotopic substitution for the elucidation of a reaction mechanism is illustrated with reactions named after Hofmann and Favorskii. These reactions have important roles in synthetic chemistry; therefore, a wide range of experiments involving isotopic labeling or kinetic isotope effects were employed to establish their mechanistic pathways. The concepts introduced by these investigations are drawn together with an isotopic labeling study of the oxidation of urea with hypohalites. The two mechanisms proposed for this reaction have been described as a Hofmann rearrangement and a nitrogen analogue of the Favorskii rearrangement.
Language eng
Field of Research 030601 Catalysis and Mechanisms of Reactions
Socio Economic Objective 970103
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2007, Boise State University
Persistent URL http://hdl.handle.net/10536/DRO/DU:30007500

Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Access Statistics: 1007 Abstract Views  -  Detailed Statistics
Created: Mon, 29 Sep 2008, 08:52:50 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.