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Evolution of class I cytokine receptors

Liongue, Clifford and Ward, Alister 2007, Evolution of class I cytokine receptors, BMC evolutionary biology, vol. 7, no. 120, pp. 1-15.

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Title Evolution of class I cytokine receptors
Author(s) Liongue, Clifford
Ward, Alister
Journal name BMC evolutionary biology
Volume number 7
Issue number 120
Start page 1
End page 15
Publisher BioMed Central
Place of publication London, England
Publication date 2007
ISSN 1471-2148
Summary Background
The Class I cytokine receptors have a wide range of actions, including a major role in the development and function of immune and blood cells. However, the evolution of the genes encoding them remains poorly understood. To address this we have used bioinformatics to analyze the Class I receptor repertoire in sea squirt (Ciona intestinalis) and zebrafish (Danio rerio).
Results
Only two Class I receptors were identified in sea squirt, one with homology to the archetypal GP130 receptor, and the other with high conservation with the divergent orphan receptor CLF-3. In contrast, 36 Class I cytokine receptors were present in zebrafish, including representative members for each of the five structural groups found in mammals. This allowed the identification of 27 core receptors belonging to the last common ancestor of teleosts and mammals.
Conclusion
This study suggests that the majority of diversification of this receptor family occurred after the divergence of urochordates and vertebrates approximately 794 million years ago (MYA), but before the divergence of ray-finned from lobe-finned fishes around 476 MYA. Since then, only relatively limited lineage-specific diversification within the different Class I receptor structural groups has occurred.
Notes This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Language eng
Field of Research 060409 Molecular Evolution
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2007, Liongue and Ward; licensee BioMed Central Ltd.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30007509

Document type: Journal Article
Collections: School of Medicine
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