Cytokine receptor signaling through the Jak-Stat-Socs pathway in disease

O`Sullivan, Lynda A., Liongue, Clifford, Lewis, Rowena S., Stephenson, Sarah E.M. and Ward, Alister 2007, Cytokine receptor signaling through the Jak-Stat-Socs pathway in disease, Molecular immunology, vol. 44, no. 10, pp. 2497-2506.

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Title Cytokine receptor signaling through the Jak-Stat-Socs pathway in disease
Author(s) O`Sullivan, Lynda A.
Liongue, Clifford
Lewis, Rowena S.
Stephenson, Sarah E.M.
Ward, Alister
Journal name Molecular immunology
Volume number 44
Issue number 10
Start page 2497
End page 2506
Publisher Pergamon - Elsevier
Place of publication Oxford, England
Publication date 2007-04
ISSN 0161-5890
1872-9142
Keyword(s) cytokine receptor
Jak–Stat–Socs
inflammatory diseases
Summary The complexity of multicellular organisms is dependent on systems enabling cells to respond to specific stimuli. Cytokines and their receptors are one such system, whose perturbation can lead to a variety of disease states. This review represents an overview of our current understanding of the cytokine receptors, Janus kinases (Jaks), Signal transducers and activators of transcription (Stats) and Suppressors of cytokine signaling (Socs), focussing on their contribution to diseases of an immune or hematologic nature.
Language eng
Field of Research 060111 Signal Transduction
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2006, Elsevier Ltd
Persistent URL http://hdl.handle.net/10536/DRO/DU:30007513

Document type: Journal Article
Collection: School of Medicine
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