Cytokine receptor signaling through the Jak-Stat-Socs pathway in disease

Cytokine receptor signaling through the Jak-Stat-Socs pathway in disease

O`Sullivan, Lynda A., Liongue, Clifford, Lewis, Rowena S., Stephenson, Sarah E.M. and Ward, Alister 2007, Cytokine receptor signaling through the Jak-Stat-Socs pathway in disease, Molecular immunology, vol. 44, no. 10, pp. 2497-2506.

Title	Cytokine receptor signaling through the Jak-Stat-Socs pathway in disease
Author(s)	O`Sullivan, Lynda A. Liongue, Clifford Lewis, Rowena S. Stephenson, Sarah E.M. Ward, Alister
Journal name	Molecular immunology
Volume number	44
Issue number	10
Start page	2497
End page	2506
Publisher	Pergamon - Elsevier
Place of publication	Oxford, England
Publication date	2007-04
ISSN	0161-5890
Keyword(s)	cytokine receptor Jak–Stat–Socs inflammatory diseases
Summary	The complexity of multicellular organisms is dependent on systems enabling cells to respond to specific stimuli. Cytokines and their receptors are one such system, whose perturbation can lead to a variety of disease states. This review represents an overview of our current understanding of the cytokine receptors, Janus kinases (Jaks), Signal transducers and activators of transcription (Stats) and Suppressors of cytokine signaling (Socs), focussing on their contribution to diseases of an immune or hematologic nature.
Language	eng
Field of Research	060111 Signal Transduction
HERDC Research category	C1 Refereed article in a scholarly journal
Copyright notice	©2006, Elsevier Ltd
Persistent URL	http://hdl.handle.net/10536/DRO/DU:30007513

Document type:	Journal Article
Collection:	School of Medicine

Citation counts:	Cited 58 times in TR Web of Science Cited 63 times in Scopus
Access Statistics:	617 Abstract Views - Detailed Statistics
Created:	Mon, 29 Sep 2008, 08:52:59 EST

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