STAT3 signaling is activated in human skeletal muscle following acute resistance exercise

Trenerry, Marissa K, Carey, Kate, Ward, Alister and Cameron-Smith, David 2007, STAT3 signaling is activated in human skeletal muscle following acute resistance exercise, Journal of applied physiology, vol. 102, no. 4, pp. 1483-1489.


Title STAT3 signaling is activated in human skeletal muscle following acute resistance exercise
Author(s) Trenerry, Marissa K
Carey, Kate
Ward, Alister
Cameron-Smith, David
Journal name Journal of applied physiology
Volume number 102
Issue number 4
Start page 1483
End page 1489
Publisher American Physiological Society
Place of publication Bethesda, Md.
Publication date 2007-04
ISSN 8750-7587
1522-1601
Keyword(s) signal transducer and activator of transcription-3
inflammation
regeneration
hypertrophy
Summary The transcription factor signal transducer and activator of transcription 3 (STAT3) has been identified as a mediator of cytokine signaling and implicated in hypertrophy; however, the importance of this pathway following resistance exercise in human skeletal muscle has not been investigated. In the present study, the phosphorylation and nuclear localization of STAT3, together with STAT3-regulated genes, were measured in the early recovery period following intense resistance exercise. Muscle biopsy samples from healthy subjects (7 males, 23.0 + 0.9 yr) were harvested before and again at 2, 4, and 24 h into recovery following a single bout of maximal leg extension exercise (3 sets, 12 repetitions). Rapid and transient activation of phosphorylated (tyrosine 705) STAT3 was observed at 2 h postexercise. STAT3 phosphorylation paralleled the transient localization of STAT3 to the nucleus, which also peaked at 2 h postexercise. Downstream transcriptional events regulated by STAT3 activation peaked at 2 h postexercise, including early responsive genes c-FOS (800-fold), JUNB (38-fold), and c-MYC (140-fold) at 2 h postexercise. A delayed peak in VEGF (4-fold) was measured 4 h postexercise. Finally, genes associated with modulating STAT3 signaling were also increased following exercise, including the negative regulator SOCS3 (60-fold). Thus, following a single bout of intense resistance exercise, a rapid phosphorylation and nuclear translocation of STAT3 are evident in human skeletal muscle. These data suggest that STAT3 signaling is an important common element and may contribute to the remodeling and adaptation of skeletal muscle following resistance exercise.
Notes First published January 4, 2007
Language eng
Field of Research 110602 Exercise Physiology
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2007, the American Physiological Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30007519

Document type: Journal Article
Collection: School of Medicine
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