Hippocampal deformation mapping in MRI-negative PET-positive temporal lobe epilepsy

Hogan, R.E., Carne, R.P., Kilpatrick, C.J., Cook, M.J., Patel, A., King, L. and O`Brien, T.J. 2008, Hippocampal deformation mapping in MRI-negative PET-positive temporal lobe epilepsy, Journal of neurology, neurosurgery and psychiatry, vol. 79, no. 6, pp. 636-640, doi: 10.1136/jnnp.2007.123406.

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Title Hippocampal deformation mapping in MRI-negative PET-positive temporal lobe epilepsy
Author(s) Hogan, R.E.
Carne, R.P.
Kilpatrick, C.J.
Cook, M.J.
Patel, A.
King, L.
O`Brien, T.J.
Journal name Journal of neurology, neurosurgery and psychiatry
Volume number 79
Issue number 6
Start page 636
End page 640
Total pages 5
Publisher BMJ Publishing Group
Place of publication London, England
Publication date 2008-06
ISSN 0022-3050
1468-330X
Summary Objectives: To compare hippocampal surface structure, using large deformation high dimensional mapping (HDM-LD), in subjects with temporal lobe epilepsy (TLE) with (HS+ve) and without (HS−ve) hippocampal sclerosis.

Methods
: The study included 30 HS−ve subjects matched with 30 HS+ve subjects from the previously reported epilepsy patient cohort. To control for normal right–left asymmetries of hippocampal surface structure, subjects were regrouped based on laterality of onset of epileptic seizures and presence of HS. Gender ratio, age, duration of epilepsy and seizure frequency were calculated for each of the four groups. Final HDM-LD surface maps of the right and left TLE groups were compared to define differences in subregional hippocampal involvement within the groups.

Results
: There were no significant differences in comparisons of the left TLE (left HS−ve compared with HS+ve) or right TLE (right HS−ve compared with HS+ve) groups with respect to age, duration of epilepsy or seizure severity scores. HDM-LD maps showed accentuated surface changes over the lateral hippocampal surface, in the region of the Sommer sector, in the hippocampi affected by HS. However, HS−ve hippocampi showed maximal surface changes in a different pattern, and did not involve the region of Sommer sector.

Conclusion
: We conclude that differences in segmental volume loss between the HS−ve and HS+ve groups are suggestive that the underlying pathophysiology of hippocampal changes in the two groups is different, and not related to chronic seizure duration or severity.
Notes Published Online First 10 October 2007
Language eng
DOI 10.1136/jnnp.2007.123406
Field of Research 110904 Neurology and Neuromuscular Diseases
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2007
Persistent URL http://hdl.handle.net/10536/DRO/DU:30007558

Document type: Journal Article
Collection: School of Medicine
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