Impaired expression of notch signaling genes in aged human skeletal muscle

Carey, Kate, Farnfield, Michelle M., Tarquino, Sarah D. and Cameron-Smith, David 2007, Impaired expression of notch signaling genes in aged human skeletal muscle, Journals of gerontology. series a: biological sciences & medical sciences, vol. 62A, no. 1, pp. 9-17.


Title Impaired expression of notch signaling genes in aged human skeletal muscle
Author(s) Carey, Kate
Farnfield, Michelle M.
Tarquino, Sarah D.
Cameron-Smith, David
Journal name Journals of gerontology. series a: biological sciences & medical sciences
Volume number 62A
Issue number 1
Start page 9
End page 17
Publisher Gerontological Society of America
Place of publication Washington, D.C.
Publication date 2007
ISSN 1079-5006
Keyword(s) notch receptor
basic helix-loop-helix transcription factors
calcium-binding proteins
gene expression regulation
intercellular signaling peptides and proteins
human skeletal muscle
muscle
Summary Notch signaling is essential for myogenesis and the regenerative potential of skeletal muscle: however, its regulation in human muscle is yet to be fully characterized. Increased expression of Notch3, Jagged1. Hes1, and Hes6 gene transcripts were observed during differentiation of cultured human skeletal muscle cells. Furthermore, significantly lower expressions of Notch1, Jagged1, Numb, and Delta-like 1 were evident in muscle biopsies from older men (60-75 years old) compared to muscle from younger men (18-25 years old). Importantly, with supervised resistance exercise training, expression of Notch1 and Hes6 genes were increased and Delta-like 1 and Numb expression were decreased. The differences in Notch expression between the age groups were no longer evident following training. These results provide further evidence to support the role of Notch in the impaired regulation of muscle mass with age and suggest that some of the benefits provided by resistance training may be mediated through the Notch signaling pathway.
Language eng
Field of Research 110308 Geriatrics and Gerontology
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2007, Gerontological Society of America
Persistent URL http://hdl.handle.net/10536/DRO/DU:30007600

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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