Increased versican content is associated with tendinosis pathology in the patellar tendon of athletes with jumper

Scott, A., Lian, O., Roberts, C., Cook, Jill, Handley, C., Bahr, R., Samiric, T., Ilic, M., Parkinson, J., Hart, D., Duronio, V. and Khan, K. 2008, Increased versican content is associated with tendinosis pathology in the patellar tendon of athletes with jumper, Scandinavian journal of medicine & science in sports, vol. 18, no. 4, pp. 427-435.

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Title Increased versican content is associated with tendinosis pathology in the patellar tendon of athletes with jumper
Author(s) Scott, A.
Lian, O.
Roberts, C.
Cook, Jill
Handley, C.
Bahr, R.
Samiric, T.
Ilic, M.
Parkinson, J.
Hart, D.
Duronio, V.
Khan, K.
Journal name Scandinavian journal of medicine & science in sports
Volume number 18
Issue number 4
Start page 427
End page 435
Publisher Wiley Interscience
Place of publication Malden, Mass.
Publication date 2008
ISSN 0905-7188
1600-0838
Keyword(s) versican
patellar tendon
tendinosis
extracellular matrix
Summary Expansion of the extracellular matrix is a prominent but poorly characterized feature of tendinosis. The present study aimed to characterize the extent and distribution of the large aggregating proteoglycan versican in patients with patellar tendinosis. We obtained tendon from tendinopathy patients undergoing debridement of the patellar tendon and from controls undergoing intramedullary tibial nailing. Versican content was investigated by Western blotting and immunohistochemistry. Microvessel thickness and density were determined using computer-assisted image analysis. Markers for smooth muscle actin, endothelial cells (CD31) and proliferating cells (Ki67) were examined immunohistochemically. Western blot analysis and immunohistochemical staining revealed elevated versican content in the proximal patellar tendon of tendinosis patients (P=0.042). Versican content was enriched in regions of fibrocartilage metaplasia and fibroblast proliferation, as well as in the perivascular matrix of proliferating microvessels and within the media and intima of arterioles. Microvessel density was higher in tendinosis tissue compared with control tissue. Versican deposition is a prominent feature of patellar tendinosis. Because this molecule is not only a component of normal fibrocartilagenous matrices but also implicated in a variety of soft tissue pathologies, future studies should further detail both pathological and adaptive roles of versican in tendons.
Notes Published Online: 7 Dec 2007
Language eng
Field of Research 111603 Systems Physiology
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2007
Copyright notice ©2007, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30007613

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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