Failure of conjugated linoleic acid supplementation to enhance biosynthesis of docosahexaenoic acid from α-linolenic acid in healthy human volunteers

Attar-Bashi, N. M., Weisinger, R. S., Begg, D. P., Sinclair, Andrew and Li, D. 2007, Failure of conjugated linoleic acid supplementation to enhance biosynthesis of docosahexaenoic acid from α-linolenic acid in healthy human volunteers, Prostaglandins, leukotrienes and essential fatty acids, vol. 76, no. 3, pp. 121-130.


Title Failure of conjugated linoleic acid supplementation to enhance biosynthesis of docosahexaenoic acid from α-linolenic acid in healthy human volunteers
Author(s) Attar-Bashi, N. M.
Weisinger, R. S.
Begg, D. P.
Sinclair, Andrew
Li, D.
Journal name Prostaglandins, leukotrienes and essential fatty acids
Volume number 76
Issue number 3
Start page 121
End page 130
Publisher Churchill Livingstone
Place of publication Edinburgh, Scotland
Publication date 2007-03
ISSN 0952-3278
1532-2823
Summary A rate-limiting step in docosahexaenoic acid (DHA) formation from α-linolenic acid (ALA) involves peroxisomal oxidation of 24:6n-3 to DHA. The aim of the study was to determine whether conjugated linoleic acid (CLA) would enhance conversion of ALA to DHA in humans on an ALA-supplemented diet. The subjects (n=8 per group) received daily supplementation of ALA (11g) and either CLA (3.2g) or placebo for 8 weeks. At baseline, 4 and 8 weeks, blood was collected for plasma fatty acid analysis and a number of physiological measures were examined. The ALA-supplemented diet increased plasma levels of ALA and eicosapentaenoic acid (EPA). The addition of CLA to the ALA diet resulted in increased plasma levels of CLA, as well as ALA and EPA. Plasma level of DHA was not increased with either the ALA alone or ALA plus CLA supplementation. The results demonstrated that CLA was not effective in enhancing DHA levels in plasma in healthy volunteers.
Notes Available online 1 February 2007.
Language eng
Field of Research 110104 Medical Biochemistry: Lipids
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2006, Elsevier Ltd
Persistent URL http://hdl.handle.net/10536/DRO/DU:30007683

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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