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Effects of gamma-tocopherol supplementation on thrombotic risk factors

Singh, Indu, Turner, Alan, Sinclair, Andrew, Li, Duo and Hawley, John 2007, Effects of gamma-tocopherol supplementation on thrombotic risk factors, Asia Pacific journal of clinical nutrition, vol. 16, no. 3, pp. 422-428.

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Title Effects of gamma-tocopherol supplementation on thrombotic risk factors
Author(s) Singh, Indu
Turner, Alan
Sinclair, Andrew
Li, Duo
Hawley, John
Journal name Asia Pacific journal of clinical nutrition
Volume number 16
Issue number 3
Start page 422
End page 428
Publisher HEC Press
Place of publication McKinnon, Vic.
Publication date 2007-09
ISSN 0964-7058
1440-6047
Keyword(s) gamma tocopherol
platelets
lipids
CRP
thrombotic risk factors
Summary Objective: The antioxidant activity of vitamin E is derived primarily from alpha-tocopherol (α-T) and gammatocopherol (γ-T). Results of epidemiological studies have demonstrated an inverse relationship between vitamin E intake and coronary disease. However, the results of clinical trials using α-T are equivocal. We determined the effect of 5 weeks of 100 mg/d or 200 mg/d γ-T supplementation on thrombotic markers such as platelet reactivity, lipid profile and the inflammation marker C-reactive protein (CRP). Methods and results: Fourteen healthy subjects consumed 100 mg/day while 13 consumed 200 mg/d of γ-T and 12 received placebo (soybean capsules with less than 5 mg/d γ-T) in a double-blinded parallel study design. Fasting pre and post dose blood samples were analysed. Blood γ-T concentrations increased significantly (p<0.05) relative to dose during the intervention period. Both groups receiving active ingredients showed significantly lower platelet activation after supplementation (p<0.05). Subjects consuming 100 mg/d γ-T had significantly decreased LDL cholesterol, platelet aggregation and mean platelet volume (MPV) (p<0.05). Little effect of γ-T was observed on other parameters. Conclusions: These data suggest that γ-T  supplementation may have a permissive role in decreasing the risk of
thrombotic events by improving lipid profile and reducing platelet activity.
Notes Reproduced with the specific permission of the copyright owner.
Language eng
Field of Research 110104 Medical Biochemistry: Lipids
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2007, HEC Press
Persistent URL http://hdl.handle.net/10536/DRO/DU:30007687

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.