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Effect of dietary omega-3 fatty acid deficiency on heart rate variability in hooded rats

Weisinger, Harrison, Salem Jr, Norman, Makino, Kevin, Hibbeln, Joseph, Sinclair, Andrew, Weisinger, Richard and DePetrillo, Paolo 2007, Effect of dietary omega-3 fatty acid deficiency on heart rate variability in hooded rats, Archives of medical science, vol. 3, no. 3, pp. 208-214.

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Title Effect of dietary omega-3 fatty acid deficiency on heart rate variability in hooded rats
Author(s) Weisinger, Harrison
Salem Jr, Norman
Makino, Kevin
Hibbeln, Joseph
Sinclair, Andrew
Weisinger, Richard
DePetrillo, Paolo
Journal name Archives of medical science
Volume number 3
Issue number 3
Start page 208
End page 214
Publisher Termedia Wydawnictwo
Place of publication Poznán, Poland
Publication date 2007
ISSN 1734-1922
1896-9151
Keyword(s) omega-3 fatty acids
heart rate variability (HRV)
Hurst exponent
Summary Introduction: Recent reports in adult humans suggest that heart rate variability is modulated by the concentration of omega-3 polyunsaturated fatty acids (PUFA) contained in blood cell membranes. Material and methods: Hurst analysis of ECG data was conducted on 12 male adult hooded (Long-Evans) rats, representing the 3rd generation to be fed diets that were either deficient in, or supplemented with, omega-3 PUFA. ECG data were obtained from surface electrodes and 4000 beats were analyzed for each animal. Results: Dietary manipulation, despite leading to large changes in tissue omega- 3 PUFA levels, did not significantly affect the complexity of heart rate dynamics, with Hurst exponent (H) values of 0.15±0.02 and 0.12±0.03, for animals fed omega- 3 fatty acid-adequate and -deficient diets, respectively. Mean heart rate was also unaffected by the diets. A power calculation revealed that about one hundred animals per group would have been required to avoid a type II error. Conclusions: According to this model of dietary PUFA manipulation, omega-3 fatty acids are unlikely to exert a large effect on the autonomic functions that control heart rate variability. Prospective studies into the effect of omega-3 fatty acids on HRV should consider the need for large sample size as estimated by the results contained in this report.
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Language eng
Field of Research 111603 Systems Physiology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2007, Termedia Wydawnictwo
Persistent URL http://hdl.handle.net/10536/DRO/DU:30007688

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.