Angiotensin converting enzyme inhibition from birth reduces body weight and body fat in Sprague-Dawley rats

Weisinger, Harrison S., Begg, Denovan P., Egan, Gary F., Jayasooriya, Anura P., Lie, Fanny, Mathai, Michael L., Sinclair, Andrew, Wark, John D. and Weisinger, Richard S. 2008, Angiotensin converting enzyme inhibition from birth reduces body weight and body fat in Sprague-Dawley rats, Physiology & behavior, vol. 93, no. 4-5, pp. 820-825.

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Title Angiotensin converting enzyme inhibition from birth reduces body weight and body fat in Sprague-Dawley rats
Author(s) Weisinger, Harrison S.
Begg, Denovan P.
Egan, Gary F.
Jayasooriya, Anura P.
Lie, Fanny
Mathai, Michael L.
Sinclair, Andrew
Wark, John D.
Weisinger, Richard S.
Journal name Physiology & behavior
Volume number 93
Issue number 4-5
Start page 820
End page 825
Total pages 6
Publisher Elsevier Inc.
Place of publication Amsterdam, The Netherlands
Publication date 2008-03-18
ISSN 0031-9384
Keyword(s) perindopril
adiposity
body composition
dual energy X-ray absorptiometry (DEXA)
magnetic resonance imaging (MRI)
blood pressure
angiotensin II
Summary In vitro studies have demonstrated that angiotensin II (ANG II) induces adipocyte hyperplasia and hypertrophy. The aim of the present study was to determine the effect of angiotensin-converting enzyme inhibition on body weight, adiposity and blood pressure in Sprague–Dawley rats. From birth half of the animals (n = 15) were given water to drink, while the remainder were administered perindopril in their drinking water (2 mg/kg/day). Food intake, water intake and body weight were measured weekly. Blood pressure was measured by tail cuff plethysmography at 11-weeks. Body fat content and distribution were assessed using dual energy X-ray absorptiometry and Magnetic Resonance Imaging at 12 weeks. Animals administered with perindopril had a body fat proportion that was half that of controls. This was consistent with, but disproportionately greater than the observed differences in food intake and body weight. Perindopril treatment completely removed hypertension. We conclude that the chronic inhibition of ANG II synthesis from birth specifically reduces the development of adiposity in the rat.
Language eng
Field of Research 111603 Systems Physiology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2007
Copyright notice ©2008, Elsevier Inc.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30007708

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
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