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Localization and expression of selenoprotein S in the testis of Psammomys obesus

Windmill, Kelly F., Tenne-Brown, Janette, Bayles, Richard, Trevaskis, James, Gao, Yuan and Walder, Ken 2007, Localization and expression of selenoprotein S in the testis of Psammomys obesus, Journal of molecular histology, vol. 38, no. 1, pp. 97-101.


Title Localization and expression of selenoprotein S in the testis of Psammomys obesus
Author(s) Windmill, Kelly F.
Tenne-Brown, Janette
Bayles, Richard
Trevaskis, James
Gao, Yuan
Walder, Ken
Journal name Journal of molecular histology
Volume number 38
Issue number 1
Start page 97
End page 101
Publisher Springer Netherlands
Place of publication Amsterdam, The Netherlands
Publication date 2007-03
ISSN 1567-2379
1567-2387
Keyword(s) Selenoprotein
SEPS1
testis
spermatogenesis
Summary Selenium is an essential trace element and selenoprotein S is a member of the selenoprotein family that has the non-standard amino acid selenocysteine incorporated into the polypeptide. Dietary selenium has been shown to play an important protective role in a number of diseases including cancer, immune function and the male reproductive system. In this study, we have observed high levels of selenoprotein S gene expression in the testis from Psammomys obesus. Real-time PCR and immunofluorescence demonstrate that selenoprotein S expression is low in testes from 4-week-old animals but increases significantly by 8 weeks of age and remains high until 17 weeks of age. Selenoprotein S protein is detected in primary spermatocytes, Leydig and Sertoli cells of 8, 12 and 17-week-old animals. These results suggest that selenoprotein S may play a role in spermatogenesis.
Notes SpringerLink Date Monday, December 18, 2006
Language eng
Field of Research 111699 Medical Physiology not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2006, Springer Science+Business Media B.V.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30007724

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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