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SEPS1 protects RAW264.7 cells from pharmacological ER stress agent-induced apoptosis

Kim, Kee-Hong, Gao, Yuan, Walder, Ken, Collier, Gregory, Skelton, Joseph and Kissebah, Ahmed H. 2007, SEPS1 protects RAW264.7 cells from pharmacological ER stress agent-induced apoptosis, Biochemical and biophysical research communications, vol. 354, no. 1, pp. 127-132.

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Title SEPS1 protects RAW264.7 cells from pharmacological ER stress agent-induced apoptosis
Author(s) Kim, Kee-Hong
Gao, Yuan
Walder, Ken
Collier, Gregory
Skelton, Joseph
Kissebah, Ahmed H.
Journal name Biochemical and biophysical research communications
Volume number 354
Issue number 1
Start page 127
End page 132
Publisher Academic Press
Place of publication Orlando, Fla.
Publication date 2007-03-02
ISSN 0006-291X
1090-2104
Keyword(s) selenoprotein S
tanis
VIMP
endoplasmic reticulum stress
macrophages
apoptosis
tunicamycin
thapsigargin
Summary Selenoprotein S (SEPS1) is a novel endoplasmic reticulum (ER) resident protein and it is known to play an important role in production of inflammatory cytokines. Here, we show evidence that SEPS1 is stimulated by pharmacological ER stress agents in RAW264.7 macrophages as well as other cell types. Overexpression studies reveal a protective action of SEPS1 in macrophages against ER stress-induced cytotoxicity and apoptosis, resulting in promoting cell survival during ER stress. The protective action of SEPS1 is largely dependent on ER stress-mediated cell death signal with less effect on non-ER stress component cell death signals. Conversely, suppression of SEPS1 in macrophages results in sensitization of cells to ER stress-induced cell death. These findings suggest that SEPS1 could be a new ER stress-dependent survival factor that protects macrophage against ER stress-induced cellular dysfunction.
Notes Available online 2 January 2007.
Language eng
Field of Research 110199 Medical Biochemistry and Metabolomics not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2006, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30007725

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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