You are not logged in.

The distribution of renal hyaluronan and the expression of hyaluronan synthases during water deprivation in the Spinifex Hopping Mouse, notomys alexis

Bartolo, Ray C. and Donald, John 2007, The distribution of renal hyaluronan and the expression of hyaluronan synthases during water deprivation in the Spinifex Hopping Mouse, notomys alexis, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, vol. 148, no. 4, pp. 853-860, doi: 10.1016/j.cbpa.2007.08.027.

Attached Files
Name Description MIMEType Size Downloads

Title The distribution of renal hyaluronan and the expression of hyaluronan synthases during water deprivation in the Spinifex Hopping Mouse, notomys alexis
Author(s) Bartolo, Ray C.
Donald, JohnORCID iD for Donald, John orcid.org/0000-0001-5930-2642
Journal name Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
Volume number 148
Issue number 4
Start page 853
End page 860
Publisher Elsevier Science
Place of publication New York, N.Y.
Publication date 2007-12
ISSN 1095-6433
1531-4332
Keyword(s) hyaluronan
hyaluronan matrix
hyaluronan synthase
kidney
notomys alexis
water deprivation
Summary Hyaluronan (HA) is a glycosaminoglycan that is synthesized by a family of enzymes called hyaluronan synthases (HASs), of which there are three isoforms (HAS1, 2 and 3) in mammals. The HASs have different tissue expression patterns and function, indicating that synthesis of HA and formation of the HA matrix may be regulated by various factors. The HA matrix has an important role in renal water handling and the production of a concentrated urine. We investigated the distribution of HA and the expression of HAS1, HAS2 and HAS3 mRNAs in the kidney of the Spinifex hopping mouse, Notomys alexis, a native Australian desert rodent that is reported to produce the most concentrated urine of any mammal. After periods of three, seven and fourteen days of water deprivation, the distribution of renal HA changed considerably, and there was a general down-regulation of HAS mRNA expression. It is proposed that the regulation of HA synthesis by the different HAS isoforms during water deprivation in N. alexis, could be influenced by the molecular mass of the HA chains produced by each isoform, followed by the rate at which the individual HAS produces HA.
Notes Available online 1 September 2007.
Language eng
DOI 10.1016/j.cbpa.2007.08.027
Field of Research 060603 Animal Physiology - Systems
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2007, Elsevier Inc.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30007815

Document type: Journal Article
Collection: School of Life and Environmental Sciences
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 4 times in TR Web of Science
Scopus Citation Count Cited 5 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 548 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Mon, 29 Sep 2008, 08:56:25 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.