Changes in body composition as determinants of longitudinal changes in bone mineral measures in 8 to 26 year old female twins

Young, D., Hopper, J. L., MacInnis, R. J., Nowson, Caryl, Hoang, N. H. and Wark, J. D. 2001, Changes in body composition as determinants of longitudinal changes in bone mineral measures in 8 to 26 year old female twins, Osteoporosis international, vol. 12, no. 6, pp. 506-515.

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Title Changes in body composition as determinants of longitudinal changes in bone mineral measures in 8 to 26 year old female twins
Author(s) Young, D.
Hopper, J. L.
MacInnis, R. J.
Nowson, Caryl
Hoang, N. H.
Wark, J. D.
Journal name Osteoporosis international
Volume number 12
Issue number 6
Start page 506
End page 515
Publisher Springer International
Place of publication London, England
Publication date 2001-06
ISSN 0937-941X
1433-2965
Keyword(s) adolescent
anthropometry
bone mass
female
longitudinal
twin study
Summary Between 1990 and 1998, we conducted a longitudinal study of 286 female twins aged 8 to 25 years at baseline (60 monozygotic (MZ) pairs, 44 dizygotic (DZ) pairs and 78 unpaired twins), measured on average 2.4 times (range 2–6) with an average of 1.8 years between measurements (range 0.7–6.7 years). Areal bone mineral density (ABMD) at the lumbar spine, total hip and femoral neck, total body bone mineral content (BMC), total body soft tissue composition (lean mass and fat mass) were measured by dual-energy X-ray absorptiometry, and height and menarchial status were also recorded. Median annual changes in height were negligible at 4 years post-menarche. During the “linear growth” period up to 4 years post-menarche, ABMD at the lumbar spine, total hip and femoral neck increased with annual change in lean mass by 1.7 (S.E. 0.1), 1.4 (0.1) and 1.0 (0.1) percent per kilogram per year, respectively (all p<0.001), independently of changes in fat mass or height. During the “post-linear growth” period, ABMD at the total hip and femoral neck increased with annual change in fat mass by 0.3 (0.1) and 0.5 (0.1) percent per kilogram per year (all p<0.01), independent of change in lean mass. Annual changes in total body BMC were associated with annual changes in lean mass (1.9 (0.2) percent per kilogram), in fat mass (1.3 (0.2) percent per kilogram) and in height (0.7) (0.2) percent per centimeter) during linear growth, and in fat mass (1.0 (0.1)) and lean mass (0.6 (0.1)) percent per kilogram post-linear growth (all p<0.001). We conclude that changes in bone mineral measures are strongly associated with changes in lean mass during linear growth, while post-linear growth, changes in fat mass are the predominant, although weaker, predictor. These findings suggest that the strong cross-sectional association between bone mineral measures and lean mass is established during growth and development, and that fat mass emerges as a more powerful determinant of bone change in healthy adult females.

Notes SpringerLink Date Friday, June 01, 2001
Language eng
Field of Research 111706 Epidemiology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2001, Springer
Persistent URL http://hdl.handle.net/10536/DRO/DU:30008387

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