In vitro effect of arsenical compounds on glutathione-related enzymes

Chouchane, Salem and Snow, Elizabeth 2001, In vitro effect of arsenical compounds on glutathione-related enzymes, Chemical research in toxicology, vol. 14, no. 5, pp. 517-522, doi: 10.1021/tx000123x.

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Title In vitro effect of arsenical compounds on glutathione-related enzymes
Author(s) Chouchane, Salem
Snow, Elizabeth
Journal name Chemical research in toxicology
Volume number 14
Issue number 5
Start page 517
End page 522
Publisher American Chemical Society
Place of publication Washington, D.C.
Publication date 2001
ISSN 0893-228X
Summary The mechanism of arsenic toxicity is believed to be due to the ability of arsenite (AsIII) to bind protein thiols. Glutathione (GSH) is the most abundant cellular thiol, and both GSH and GSH-related enzymes are important antioxidants that play an important role in the detoxification of arsenic and other carcinogens. The effect of arsenic on the activity of a variety of enzymes that use GSH has been determined using purified preparations of glutathione reductase (GR) from yeast and bovine glutathione peroxidase (GPx) and equine glutathione S-transferase (GST). The effect on enzyme activity of increasing concentrations (from 1 μM to 100 mM) of commercial sodium arsenite (AsIII) and sodium arsenate (AsV) and a prepared arsenic(III)−glutathione complex [AsIII(GS)3] and methylarsenous diiodide (CH3AsIII) has been examined.
Language eng
DOI 10.1021/tx000123x
Field of Research 111506 Toxicology (incl Clinical Toxicology)
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2001, American Chemical Society
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