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The evidence that exercise during growth or adulthood reduces the risk of fragility fractures is weak

Karlsson, Magnus, Bass, Shona and Seeman, Ego 2001, The evidence that exercise during growth or adulthood reduces the risk of fragility fractures is weak, Bailliere`s best Practice & Reseach in Clinical Rheumatology, vol. 15, no. 3, pp. 429-450, doi: 10.1053/berh.2001.0159.

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Title The evidence that exercise during growth or adulthood reduces the risk of fragility fractures is weak
Author(s) Karlsson, Magnus
Bass, Shona
Seeman, Ego
Journal name Bailliere`s best Practice & Reseach in Clinical Rheumatology
Volume number 15
Issue number 3
Start page 429
End page 450
Publisher Bailliere Tindall
Place of publication London, England
Publication date 2001-07
ISSN 1521-6942
Keyword(s) muscle strength
muscle mass
bone mass
bone structure
falls
injurious falls
fragility fractures
fracture prevention
Summary There has never been, and will never be, a randomized double-blind placebo-controlled trial demonstrating that exercise in youth, adulthood or old age reduces fragility or osteoporosis-related fractures in old age. The next level of evidence, a randomized, controlled but unblinded study with fractures as an end-point is feasible but has never been done. The basis for the belief that exercise reduces fractures is derived from lower levels of ‘evidence’, namely, retrospective and prospective observation cohort studies and case–control studies. These studies are at best hypothesis generating, never hypothesis testing. They are all subject to many systematic biases and should be interpreted with extreme scepticism. Surrogate measures of anti-fracture efficacy are the next level of evidence, such as the demonstration of a reduction in risk factors for falls, a reduction in falls, a reduction in fractures due to falls, an increase in peak bone size and mass, prevention of bone loss in midlife and restoration of bone mass and structure in old age.
Language eng
DOI 10.1053/berh.2001.0159
Field of Research 110306 Endocrinology
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2001, Harcourt Publishers Ltd.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30008427

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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