Nucleic acid vaccines: tasks and tactics

McKenzie, Brent S., Corbett, Alexandra J., Brady, Jamie L., Dyer, Christopher M., Strugnell, Richard A., Kent, Stephen J., Kramer, David, Boyle, Jefferey S. and Lew, Andrew M. 2001, Nucleic acid vaccines: tasks and tactics, Immunologic research, vol. 24, no. 3, pp. 225-244.

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Title Nucleic acid vaccines: tasks and tactics
Author(s) McKenzie, Brent S.
Corbett, Alexandra J.
Brady, Jamie L.
Dyer, Christopher M.
Strugnell, Richard A.
Kent, Stephen J.
Kramer, David
Boyle, Jefferey S.
Lew, Andrew M.
Journal name Immunologic research
Volume number 24
Issue number 3
Start page 225
End page 244
Publisher Humana Press, Inc.
Place of publication Totowa, N.J.
Publication date 2001-12
ISSN 0257-277x
Keyword(s) DNA vaccines
genetic vaccines
RNA vacinnes
Summary There are no adequate vaccines against some of the new or reemerged infectious scourges such as HIV and TB. They may require strong and enduring cell-mediated immunity to be elicited. This is quite a task, as the only known basis of protection by current commercial vaccines is antibody. As DNA or RNA vaccines may induce both cell-mediated and humoral immunity, great interest has been shown in them. However, doubt remains whether their efficacy will suffice for their clinical realization. We look at the various tactics to increase the potency of nucleic acid vaccines and divided them broadly under those affecting delivery and those affecting immune induction. For delivery, we have considered ways of improving uptake and the use of bacterial, replicon or viral vectors. For immune induction, we considered aspects of immunostimulatory CpG motifs, coinjection of cytokines or costimulators and alterations of the antigen, its cellular localization and its anatomical localization including the use of ligand-targeting to lymphoid tissue. We also thought that mucosal application of DNA deserved a separate section. In this review, we have taken the liberty to discuss these enhancement methods, whenever possible, in the context of the underlying mechanisms that might argue for or against these strategies.
Language eng
Field of Research 110799 Immunology not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2001
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