Plasma glucose kinetics during prolonged exercise in trained humans when fed carbohydrate

Angus, Damien J., Febbraio, Mark A. and Hargreaves, Mark 2002, Plasma glucose kinetics during prolonged exercise in trained humans when fed carbohydrate, American journal of physiology: endocrinology and metabolism, vol. 283, no. 3, pp. 573-577.

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Title Plasma glucose kinetics during prolonged exercise in trained humans when fed carbohydrate
Author(s) Angus, Damien J.
Febbraio, Mark A.
Hargreaves, Mark
Journal name American journal of physiology: endocrinology and metabolism
Volume number 283
Issue number 3
Start page 573
End page 577
Publisher American Physiological Society
Place of publication Bethesda, MD
Publication date 2002-09
ISSN 0193-1849
1522-1555
Keyword(s) Glucose uptake
Glucose production
Glycogenolysis
Summary Nine endurance-trained men exercised on a cycle ergometer at ~68% peak O2 uptake to the point of volitional fatigue [232 ± 14 (SE) min] while ingesting an 8% carbohydrate solution to determine how high glucose disposal could increase under physiological conditions. Plasma glucose kinetics were measured using a primed, continuous infusion of [6,6-2H]glucose and the appearance of ingested glucose, assessed from [3-3H]glucose that had been added to the carbohydrate drink. Plasma glucose was increased (P < 0.05) after 30 min of exercise but thereafter remained at the preexercise level. Glucose appearance rate (Ra) increased throughout exercise, reaching its peak value of 118 ± 7 µmol · kg-1 · min-1 at fatigue, whereas gut Ra increased continuously during exercise, peaking at 105 ± 10 µmol · kg-1 · min-1 at the point of fatigue. In contrast, liver glucose output never rose above resting levels at any time during exercise. Glucose disposal (Rd) increased throughout exercise, reaching a peak value of 118 ± 7 µmol · kg-1 · min-1 at fatigue. If we assume 95% oxidation of glucose Rd, estimated exogenous glucose oxidation at fatigue was 1.36 ± 0.08 g/min. The results of this study demonstrate that glucose uptake increases continuously during prolonged, strenuous exercise when carbohydrate is ingested and does not appear to limit exercise performance.
Language eng
Field of Research 060104 Cell Metabolism
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2002, The American Physiology Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30008524

Document type: Journal Article
Collection: School of Health Sciences
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