G-CSF: function and modes of action (Review)

Basu, S., Dunn, A. and Ward, Alister 2002, G-CSF: function and modes of action (Review), International journal of molecular medicine, vol. 10, no. 1, pp. 3-10.

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Title G-CSF: function and modes of action (Review)
Author(s) Basu, S.
Dunn, A.
Ward, Alister
Journal name International journal of molecular medicine
Volume number 10
Issue number 1
Start page 3
End page 10
Publisher Spandidos Publications
Place of publication Athens, Greece
Publication date 2002-07
ISSN 1107-3756
1791-244X
Keyword(s) haematology
Summary Since the observations in the 1960s that granulocyte-colony stimulating factor (G-CSF) stimulated the proliferation of granulocytic cells in semisolid cultures of bone marrow cells, G-CSF has established itself as a useful clinical agent for increasing levels of neutrophilic granulocytes. However, these early findings did not firmly establish whether G-CSF is a genuine regulator of granulocyte formation under normal physiological conditions or rather acts as an emergency regulator, playing an important role only under stress conditions. The advent of <gene-knockout technology> has allowed us to evaluate these questions in a physiological setting through analysis of mice with a targeted mutation of G-CSF or its receptor, while the development of relevant cell models has enabled us to dissect the molecular basis of G-CSF action. This review discusses our current state of knowledge regarding the role of G-CSF in granulopoiesis.
Language eng
Field of Research 110202 Haematology
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2002, Spandidos Publications Ltd
Persistent URL http://hdl.handle.net/10536/DRO/DU:30008544

Document type: Journal Article
Collection: School of Medicine
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