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Dietary conjugated linoleic acid differentially alters fatty acid composition and increases conjugated linoleic acid content in porcine adipose tissue

Ostrowska, Ewa, Cross, Reg F., Muralitharan, Morley, Bauman, Dale E. and Dunshea, Frank R. 2003, Dietary conjugated linoleic acid differentially alters fatty acid composition and increases conjugated linoleic acid content in porcine adipose tissue, British journal of nutrition, vol. 90, no. 5, pp. 915-928, doi: 10.1079/BJN2003982.

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Title Dietary conjugated linoleic acid differentially alters fatty acid composition and increases conjugated linoleic acid content in porcine adipose tissue
Author(s) Ostrowska, Ewa
Cross, Reg F.
Muralitharan, Morley
Bauman, Dale E.
Dunshea, Frank R.
Journal name British journal of nutrition
Volume number 90
Issue number 5
Start page 915
End page 928
Publisher CABI Publishing
Place of publication Cambrigde, England
Publication date 2003-11
ISSN 0007-1145
1475-2662
Keyword(s) conjugated linoleic acid
fatty acids
pigs
Summary Conjugated linoleic acids (CLA) have been shown to decrease body fat content in pigs. It is possible that feeding pigs diets rich in CLA may increase carcass lipid CLA to levels that could provide health benefits when included as a part of a healthy diet. Therefore, the aim of the present study was to determine whether dietary CLA supplementation has any effect on the fatty acid composition of subcutaneous and intramuscular adipose tissue in pigs. Thirty-five female cross bred (Large White X Landrace) pigs (initial weight 57·2 kg and initial P2 back fat 11·5 mm) were used in the present study. Pigs were housed individually and randomly allocated to one of six dietary treatments (0·00, 1·25, 2·50, 5·00, 7·50 and 10·00 g CLA55 (55 g CLA isomers/100 g total fatty acids; Natural Lipids Ltd, Hovdebygda, Norway)/kg)
and fed their respective diets for 8 weeks. Twelve CLA isomers in the diet and in pig tissue lipids were separated by Agþ-HPLC. CLA was incorporated at fivefold higher levels in subcutaneous fat as compared with intramuscular fat and in a dose-dependant manner. Overall, the transfer efficiency of CLA was maximized at 5·00 g CLA55/kg. However, there was clear selectivity in the uptake or incorporation of cis,trans-9,11 isomer over the trans,cis-10,12 isomer. In general, CLA supplementation produced significant changes in skeletal muscle and adipose tissue fatty acid composition, indicating that dietary CLA had a potent affect on lipid transport and metabolism in vivo. Significant increases in myristic, palmitic and palmitoleic acids and a reduction in arachidonic acid were observed, suggesting an alteration in
activity of Δ5-, Δ6- and Δ9-desaturases in pig adipose tissue. In conclusion, feeding pigs diets supplemented with CLA increases carcass lipid CLA, but also results in changes in the fatty acid profile in pig fat that could potentially outweigh the benefits of CLA.
Language eng
DOI 10.1079/BJN2003982
Field of Research 060602 Animal Physiology - Cell
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2003, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30008576

Document type: Journal Article
Collections: School of Biological and Chemical Sciences
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.