Sustained weight loss in obese subjects has benefits that are independent of attained weight

Dixon, John, Anderson, Margaret, Cameron-Smith, David and O`Brien, Paul 2004, Sustained weight loss in obese subjects has benefits that are independent of attained weight, Obesity Research, vol. 12, no. 11, pp. 1895-1902.

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Title Sustained weight loss in obese subjects has benefits that are independent of attained weight
Author(s) Dixon, John
Anderson, Margaret
Cameron-Smith, David
O`Brien, Paul
Journal name Obesity Research
Volume number 12
Issue number 11
Start page 1895
End page 1902
Publisher North American Association for the Study of Obesity
Place of publication Baton Rouge, La.
Publication date 2004-11
ISSN 1071-7323
1930-739X
Keyword(s) Postobese
Metabolic
Gastric
Band
Homocysteine
Summary Objective: To explore the hypothesis that sustained weight loss in severely obese patients may have benefits that are independent of their attained BMI. Research Methods and Procedures: We conducted a comparison of two weight-stable groups with BMI in the 30 to 35 kg/m2 range. Subjects (n = 79) were selected obese patients 3 years after laparoscopic adjustable gastric band surgery, and controls (n = 79) were obese patients seeking weight loss therapy. Subjects were selected in a de-identified manner from our database to best match the control group. A range of clinical, biochemical, and questionnaire measures were obtained to assess obesity-related health status Results: Subjects maintained a mean weight loss of 32.8 plusminus 18 kg after surgery. The weight loss subjects had significantly lower fasting plasma glucose, insulin, and triglyceride concentrations, along with higher high-density lipoprotein-cholesterol levels and better indirect measures of insulin sensitivity when compared with controls (p < 0.05 for all). In addition, aminotransferase levels, neutrophil counts, and globulin levels were also significantly lower in weight loss subjects. All differences in laboratory variables remained significant after controlling for BMI. The subjects also reported better health-related quality of life, fewer symptoms of depression, and greater satisfaction with their appearance than controls. Discussion: These findings suggest that the post-weight loss state conveys benefits that are greater than predicted by the attained BMI. These findings may have important implications regarding the expectations of weight loss therapy, and mechanisms for this effect should be carefully sought.
Language eng
Field of Research 110306 Endocrinology
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2004, NAASO
Persistent URL http://hdl.handle.net/10536/DRO/DU:30008688

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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