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The Omp85 family of proteins is essential for outer membrane biogenesis in mitochondria and bacteria

Gentle, Ian, Gabriel, Kipros, Beech, Peter, Waller, Ross and Lithgow, Trevor 2004, The Omp85 family of proteins is essential for outer membrane biogenesis in mitochondria and bacteria, Journal of cell biology, vol. 164, no. 1, pp. 19-24, doi: 10.1083/jcb.200310092.

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Title The Omp85 family of proteins is essential for outer membrane biogenesis in mitochondria and bacteria
Author(s) Gentle, Ian
Gabriel, Kipros
Beech, Peter
Waller, Ross
Lithgow, Trevor
Journal name Journal of cell biology
Volume number 164
Issue number 1
Start page 19
End page 24
Publisher Rockefeller University Press
Place of publication New York, N.Y.
Publication date 2004
ISSN 0021-9525
Keyword(s) endosymbiont theory
membrane biogenesis
ß-barrel protein
mitochondria
protein import
Summary Integral proteins in the outer membrane of mitochondria control all aspects of organelle biogenesis, being required for protein import, mitochondrial fission, and, in metazoans, mitochondrial aspects of programmed cell death. How these integral proteins are assembled in the outer membrane had been unclear. In bacteria, Omp85 is an essential component of the protein insertion machinery, and we show that members of the Omp85 protein family are also found in eukaryotes ranging from plants to humans. In eukaryotes, Omp85 is present in the mitochondrial outer membrane. The gene encoding Omp85 is essential for cell viability in yeast, and conditional omp85 mutants have defects that arise from compromised insertion of integral proteins like voltage-dependent anion channel (VDAC) and components of the translocase in the outer membrane of mitochondria (TOM) complex into the mitochondrial outer membrane.
Notes Published online 29 December 2003
Language eng
DOI 10.1083/jcb.200310092
Field of Research 060110 Receptors and Membrane Biology
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2004, The Rockefeller University Press
Persistent URL http://hdl.handle.net/10536/DRO/DU:30008691

Document type: Journal Article
Collections: School of Biological and Chemical Sciences
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.