The effect of calcium supplementation on bone density in premenarcheal females: a co-twin approach

Cameron, Melissa A., Paton, Lynda M., Nowson, Caryl, Margerison, Claire, Frame, Mandy and Wark, John D. 2004, The effect of calcium supplementation on bone density in premenarcheal females: a co-twin approach, Journal of clinical endocrinology and metabolism, vol. 89, no. 10, pp. 4916-4922, doi: 10.1210/jc.2003-031985.

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Title The effect of calcium supplementation on bone density in premenarcheal females: a co-twin approach
Author(s) Cameron, Melissa A.
Paton, Lynda M.
Nowson, CarylORCID iD for Nowson, Caryl
Margerison, ClaireORCID iD for Margerison, Claire
Frame, Mandy
Wark, John D.
Journal name Journal of clinical endocrinology and metabolism
Volume number 89
Issue number 10
Start page 4916
End page 4922
Publisher Endocrine Society
Place of publication Baltimore, MD
Publication date 2004
ISSN 0021-972X
Summary The age and developmental stage at which calcium supplementation produces the greatest bone effects remain controversial. We tested the hypothesis that calcium supplementation may improve bone accrual in premenarcheal females. Fifty-one pairs of premenarcheal female twins (27 monozygotic and 24 dizygotic; mean ± SD age, 10.3 ± 1.5 yr) participated in a randomized, single-blind, placebo-controlled trial with one twin of each pair receiving a 1200-mg calcium carbonate (Caltrate) supplement. Areal bone mineral density (aBMD) was measured at baseline and 6, 12, 18 and 24 months. There were no within-pair differences in height, weight, or calcium intake at baseline. Calcium supplementation was associated (P < 0.05) with increased aBMD compared with placebo, adjusted for age, height, and weight at the following time points from baseline: total hip, 6 months (1.9%), 12 months (1.6%), and 18 months (2.4%); lumbar spine, 12 months (1.0%); femoral neck, 6 months (1.9%). Adjusted total body bone mineral content was higher in the calcium group at 6 months (2.0%), 12 months (2.5%), 18 months (4.6%), and 24 months (3.7%), respectively (all P < 0.001). Calcium supplementation was effective in increasing aBMD at regional sites over the first 12–18 months, but these gains were not maintained to 24 months.

Language eng
DOI 10.1210/jc.2003-031985
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2004, Endocrine Society
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