Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the third national health and nutrition examination survey

Scragg, Robert, Sowers, MaryFran and Bell, Colin 2004, Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the third national health and nutrition examination survey, Diabetes care, vol. 27, no. 12, pp. 2813-2818, doi: 10.2337/diacare.27.12.2813.

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Title Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the third national health and nutrition examination survey
Author(s) Scragg, Robert
Sowers, MaryFran
Bell, ColinORCID iD for Bell, Colin
Journal name Diabetes care
Volume number 27
Issue number 12
Start page 2813
End page 2818
Publisher American Diabetes Association
Place of publication Alexandria, Va.
Publication date 2004-12
ISSN 0149-5992
Summary OBJECTIVE— To determine the association between serum 25-hydroxyvitamin D (25OHD) and diabetes risk and whether it varies by ethnicity.
RESEARCH DESIGN AND METHODS— We performed an analysis of data from participants who attended the morning examination of the Third National Health and Nutrition Examination Survey (1988–1994), a cross-sectional survey of a nationally representative sample of the U.S. population. Serum levels of 25OHD, which reflect vitamin D status, were available from 6,228 people (2,766 non-Hispanic whites, 1,736 non-Hispanic blacks, and 1,726 Mexican Americans) aged ≥20 years with fasting and/or 2-h plasma glucose and serum insulin measurements.
RESULTS— Adjusting for sex, age, BMI, leisure activity, and quarter of year, ethnicityspecific odds ratios (ORs) for diabetes (fasting glucose ≥7.0 mmol/l) varied inversely across quartiles of 25OHD in a dose-dependent pattern (OR 0.25 [95% CI 0.11– 0.60] for non-Hispanic whites and 0.17 [0.08–0.37] for Mexican Americans) in the highest vitamin D quartile (25OHD ≥81.0 nmol/l) compared with the lowest 25OHD (≥43.9 nmol/l). This inverse association
was not observed in non-Hispanic blacks. Homeostasis model assessment of insulin resistance (loge) was inversely associated with serum 25OHD in Mexican Americans (P ≥ 0.0024) and non-Hispanic whites (P≥0.058) but not non-Hispanic blacks (P≥0.93), adjusting for confounders.
CONCLUSIONS— These results show an inverse association between vitamin D status and diabetes, possibly involving insulin resistance, in non-Hispanic whites and Mexican Americans. The lack of an inverse association in non-Hispanic blacks may reflect decreased sensitivity to vitamin D and/or related hormones such as the parathyroid hormone.
Language eng
DOI 10.2337/diacare.27.12.2813
Field of Research 111706 Epidemiology
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2004, American Diabetes Association
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Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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