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Effects of dietary conjugated linoleic acid on haematological and humoral responses in the grower pig

Ostrowska, E., Knowles, A., Muralitharan, Morley, Cross, R., Bauman, D. and Dunshea, Frank 2004, Effects of dietary conjugated linoleic acid on haematological and humoral responses in the grower pig, Australian journal of agricultural research, vol. 55, no. 7, pp. 711-718, doi: 10.1071/AR04002.

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Title Effects of dietary conjugated linoleic acid on haematological and humoral responses in the grower pig
Author(s) Ostrowska, E.
Knowles, A.
Muralitharan, Morley
Cross, R.
Bauman, D.
Dunshea, Frank
Journal name Australian journal of agricultural research
Volume number 55
Issue number 7
Start page 711
End page 718
Publisher CSIRO Publishing
Place of publication Melbourne, Vic.
Publication date 2004
ISSN 0004-9409
Summary The effects of conjugated linoleic acid (CLA) on the levels of total serum leucocytes, granulocytes including neutrophils, basophils, and eosinophils, as well as on monocytes and leucocytes were measured in pigs selected from a clean (minimal disease) herd. Thirty pigs were fed different rates of dietary CLA (0, 1.25, 2.5, 5.0, 7.5, and 10.0 g CLA-55/kg diet) for 8 weeks. Blood samples were collected at the end of the study for assessment of haematological and humoral responses to CLA supplementation. No difference in total white blood cells including the neutrophil, monocyte, and lymphocyte counts was observed among different dietary groups. A dose-dependent reduction (P = 0.02) in eosinophil concentrations suggests that CLA exerts anti-inflammatory activities. A 2-fold increase in the level of basophils was recorded in pigs fed lower levels of CLA (1.25 and 2.5 g CLA/kg diet) but the levels decreased gradually (P = 0.05) and were below the detection limit at the highest rate (10 g/kg) of CLA supplementation. The level of IgG was reduced by over 50% in CLA-fed pigs (P < 0.001), although the response was quadratic in nature (P < 0.001). T-cell population analysis showed that CD4+ cells tended (P = 0.06) to be reduced linearly with increasing inclusion of CLA in the diet. Our results suggest that dietary CLA modulates haematological and humoral responses in a dose-dependent manner.
Language eng
DOI 10.1071/AR04002
Field of Research 060603 Animal Physiology - Systems
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2004, CSIRO
Persistent URL http://hdl.handle.net/10536/DRO/DU:30008750

Document type: Journal Article
Collection: School of Biological and Chemical Sciences
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