Blood-nourishing and hard-softening capsule costs less in the management of osteoarthriticknee pain : A randomized controlled trial

Cao, Yuelong, Shi, Yinyu, Zheng, Yuxing, Shi, Meiyu and Lo, Sing Kai 2005, Blood-nourishing and hard-softening capsule costs less in the management of osteoarthriticknee pain : A randomized controlled trial, Evidence - based complementary and alternative medicine, vol. 2, no. 3, pp. 363-368.

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Title Blood-nourishing and hard-softening capsule costs less in the management of osteoarthriticknee pain : A randomized controlled trial
Author(s) Cao, Yuelong
Shi, Yinyu
Zheng, Yuxing
Shi, Meiyu
Lo, Sing Kai
Journal name Evidence - based complementary and alternative medicine
Volume number 2
Issue number 3
Start page 363
End page 368
Publisher Oxford University Press
Place of publication Oxford, England
Publication date 2005-07-26
ISSN 1741-427X
Keyword(s) Chinese herbal medicine
chondroprotection drug
WOMAC
herbal medicine
Summary The blood-nourishing and hard-softening (BNHS) capsule is a traditional Chinese formula used in the symptomatic treatment of inflammation and pain. We conducted this randomized controlled trial to compare the efficacy of BNHS with other commonly prescribed drugs. We recruited 120 patients from two teaching hospitals; 30 patients in each hospital were randomly assigned to receive BNHS. In one hospital, the 30 controls were given another traditional Chinese drug; whereas a Western medicine (chondroprotection drug/Viartril-s) was used as the control in the other hospital. Intervention was carried out over a period of 4 weeks. Primary outcome measures included self-reported pain level, and changes in stiffness and functional ability as measured by the Western Ontario McMaster Universities Osteoarthritis (WOMAC) index. Mixed models were used for statistical analysis. Substantial improvements in disease-specific symptoms were observed, after 4 weeks of treatment, in patients taking BNHS capsules. As assessed by the WOMAC index, pain level of the BNHS group decreased by 57% [95% confidence interval (CI) = 50, 63], stiffness by 63% (95% CI = 55, 71) and functional ability increased by 56% (95% CI = 50, 63). No significant differences were found in any of the outcome measures between the BNHS group and either of the comparison groups. No severe adverse effects were reported. However, this study lacked a placebo group; therefore, we conclude that BNHS appears to be as effective as commonly prescribed medicines for the relief of pain and dysfunction in knee osteoarthritis patients, but costs a lot less than other Western and herbal drugs in the study.
Language eng
Field of Research 110404 Traditional Chinese Medicine and Treatments
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type X Not reportable
Copyright notice ©2005, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30008847

Document type: Journal Article
Collection: School of Psychology
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