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Alterations in the proportions of skeletal muscle proteins following a unilateral lesion to the substantia nigra pars compacta of rats

Sliwinski, A., Stanic, D., Finklestein, D.I., Ilic, M., West, Jan and Dooley, P.C. 2005, Alterations in the proportions of skeletal muscle proteins following a unilateral lesion to the substantia nigra pars compacta of rats, Journal of muscle research and cell motility, vol. 26, no. 2-3, pp. 149-155, doi: 10.1007/s10974-005-6833-7.

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Title Alterations in the proportions of skeletal muscle proteins following a unilateral lesion to the substantia nigra pars compacta of rats
Author(s) Sliwinski, A.
Stanic, D.
Finklestein, D.I.
Ilic, M.
West, JanORCID iD for West, Jan orcid.org/0000-0003-1112-6082
Dooley, P.C.
Journal name Journal of muscle research and cell motility
Volume number 26
Issue number 2-3
Start page 149
End page 155
Publisher Springer-Verlag
Place of publication Dordrecht, Netherlands
Publication date 2005-04
ISSN 0142-4319
1573-2657
Keyword(s) substantia nigra pars compacta
lesion
skeletal muscle
regulatory proteins
contractile proteins
rat
Summary It is well established that mammalian skeletal muscles exhibit a considerable degree of plasticity and one of the main determining factors of this plasticity is the activity pattern and duration of motoneurone discharge. Lesions to the right substantia nigra pars compacta (SNpc) of six adult rats were made to determine whether altered output from the SNpc ultimately leads to a change in the expression of proteins in contralateral skeletal muscles. After 4 months, altered motor performance was identified by the administration of amphetamine. After 7 months, 30–70% of dopaminergic cells in the SNpc had been destroyed. The protein content of muscles was then quantified from densitometric scans of gels, and expressed as a % of the amount of actin (the protein used as a reference in this study). The lesion affected the expression of different protein isoforms in the fast- and slow-twitch muscles. In slow-twitch soleus muscles, the lesion decreased the proportion of α-tropomyosin and increased the proportion of β-tropomyosin. In the fast-twitch extensor digitorum longus muscles, the lesion increased the proportion of the fast isoform of troponin-T1f, and decreased the proportions of the two isoforms of myosin light chain. This study establishes a connection between the chronic effects of a lesion to the SNpc, with a loss of dopaminergic neurones, impaired motor performance, and altered expression of proteins in skeletal muscle. The implication of these results is that the altered motor function observed in Parkinson’s disease may be associated with alterations to the expression of skeletal muscle proteins.
Language eng
DOI 10.1007/s10974-005-6833-7
Field of Research 060699 Physiology not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2005, Springer-Verlag
Persistent URL http://hdl.handle.net/10536/DRO/DU:30008868

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