Optimal H∞ insulin injection control for blood glucose regulation in diabetic patients
Chee, Frederick, Savkin, Andrey V., Fernando, Tyrone L. and Nahavandi, Saeid 2005, Optimal H∞ insulin injection control for blood glucose regulation in diabetic patients, IEEE transactions of biomedical engineering, vol. 52, no. 10, pp. 1625-1631.
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The theory of H/sup /spl infin// optimal control has the feature of minimizing the worst-case gain of an unknown disturbance input. When appropriately modified, the theory can be used to design a "switching" controller that can be applied to insulin injection for blood glucose (BG) regulation. The "switching" controller is defined by a collection of basic insulin rates and a rule that switches the insulin rates from one value to another. The rule employed an estimation of BG from noisy measurements, and the subsequent optimization of a performance index that involves the solution of a "jump" Riccati differential equation and a discrete-time dynamic programming equation. With an appropriate patient model, simulation studies have shown that the controller could correct BG deviation using clinically acceptable insulin delivery rates.
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Field of Research
110306 Endocrinology 090399 Biomedical Engineering not elsewhere classified
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