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Optimal H∞ insulin injection control for blood glucose regulation in diabetic patients

Chee, Frederick, Savkin, Andrey V., Fernando, Tyrone L. and Nahavandi, Saeid 2005, Optimal H∞ insulin injection control for blood glucose regulation in diabetic patients, IEEE transactions of biomedical engineering, vol. 52, no. 10, pp. 1625-1631.

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Title Optimal H∞ insulin injection control for blood glucose regulation in diabetic patients
Formatted title Optimal H∞ insulin injection control for blood glucose regulation in diabetic patients
Author(s) Chee, Frederick
Savkin, Andrey V.
Fernando, Tyrone L.
Nahavandi, Saeid
Journal name IEEE transactions of biomedical engineering
Volume number 52
Issue number 10
Start page 1625
End page 1631
Publisher IEEE Xplore
Place of publication Piscataway, N.J.
Publication date 2005-10
ISSN 0018-9294
Summary The theory of H/sup /spl infin// optimal control has the feature of minimizing the worst-case gain of an unknown disturbance input. When appropriately modified, the theory can be used to design a "switching" controller that can be applied to insulin injection for blood glucose (BG) regulation. The "switching" controller is defined by a collection of basic insulin rates and a rule that switches the insulin rates from one value to another. The rule employed an estimation of BG from noisy measurements, and the subsequent optimization of a performance index that involves the solution of a "jump" Riccati differential equation and a discrete-time dynamic programming equation. With an appropriate patient model, simulation studies have shown that the controller could correct BG deviation using clinically acceptable insulin delivery rates.
Notes This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder.
Language eng
Field of Research 110306 Endocrinology
090399 Biomedical Engineering not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2005, IEEE
Persistent URL http://hdl.handle.net/10536/DRO/DU:30008902

Document type: Journal Article
Collections: School of Engineering and Technology
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