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Low dose supplementation with two different marine oils does not reduce pro-inflammatory eicosanoids and cytokines in vivo

Murphy, Karen J., Galvin, Karen, Kiely, Mairead, Morrissey, Patrick A., Mann, Neil J. and Sinclair, Andrew 2006, Low dose supplementation with two different marine oils does not reduce pro-inflammatory eicosanoids and cytokines in vivo, Asia Pacific journal of clinical nutrition, vol. 15, no. 3, pp. 418-424.

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Title Low dose supplementation with two different marine oils does not reduce pro-inflammatory eicosanoids and cytokines in vivo
Formatted title Low dose supplementation with two different marine oils does not reduce pro-inflammatory eicosanoids and cytokines in vivo
Author(s) Murphy, Karen J.
Galvin, Karen
Kiely, Mairead
Morrissey, Patrick A.
Mann, Neil J.
Sinclair, Andrew
Journal name Asia Pacific journal of clinical nutrition
Volume number 15
Issue number 3
Start page 418
End page 424
Publisher HEC Press
Place of publication McKinnon, Vic.
Publication date 2006-09
ISSN 0964-7058
1440-6047
Keyword(s) NZGLM
fatty acids
n-3 LCPUFA
eicosanoid
cytokine
gas chromatography
Summary In view of the reported potential anti-inflammatory activity of the New Zealand green lipped mussel (NZGLM), we aimed to compare the effect of low dose marine oil supplementation, from mussels and fish, in reducing blood markers of inflammation. Thirty apparently healthy males and females were recruited from the general public in Melbourne, Australia to participate in a double blind, randomised, parallel intervention study. Subjects were consuming approximately 73 mg of omega-3 long chain polyunsaturated fatty acids (n-3 LCPUFA) daily in their background diet prior to the commencement of the intervention. Subjects were randomly assigned to consume either 2 mL/day of the NZGLM oil preparation (mixed with olive oil and dl-alpha-tocopherol) or fish oil preparation (also mixed with olive oil and dl-alpha-tocopherol) for six weeks. Two mL of the oils contained 241 mg and 181 mg of n-3 LCPUFA, respectively. Neutrophil phospholipid fatty acids, serum thromboxane B2 (TXB2), stimulated monocyte production of prostaglandin E2 (PGE2), interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha (TNFalpha) were measured. During the intervention, the total intakes of n-3 LCPUFA from the background diet and the supplements were 199 mg/d and 173 mg/day for the NZGLM and FO groups, respectively. Following six weeks of supplementation, both groups showed a small, but significant increase in neutrophil phospholipid proportion of eicosapentaenoic acid. The NZGLM group also showed a significant increase in docosahexaenoic acid levels. There were no significant changes with time or treatment for TXB2, PGE2, IL-1 beta or TNFalpha. This study showed that low dose supplementation with n-3 LCPUFA from two different marine oil preparations showed no difference in inflammatory markers in this group of healthy individuals. Further studies are warranted including dose response trials and studies in populations with inflammatory conditions.
Notes Reproduced with the specific permission of the copyright owner.
Language eng
Field of Research 110322 Rheumatology and Arthritis
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2006, HEC Press
Persistent URL http://hdl.handle.net/10536/DRO/DU:30009061

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
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Created: Mon, 13 Oct 2008, 15:50:00 EST