Lupin (Lupinus albus) protein isolate (L-ISO) has adequate nutritional value and reduces large intestinal weight in rats after restricted and ad libitum feeding.

Caligari, Silvia, Chiesa, Giulia, Johnson, Stuart K., Camiassai, Davide, Gillio, Donatella, Marchesi, Marta, Parolini, Cinzia, Rubio, Luis A. and Sirtori, Cesare R. 2006, Lupin (Lupinus albus) protein isolate (L-ISO) has adequate nutritional value and reduces large intestinal weight in rats after restricted and ad libitum feeding., Annals of nutrition and metabolism, vol. 50, no. 6, pp. 528-537.

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Title Lupin (Lupinus albus) protein isolate (L-ISO) has adequate nutritional value and reduces large intestinal weight in rats after restricted and ad libitum feeding.
Author(s) Caligari, Silvia
Chiesa, Giulia
Johnson, Stuart K.
Camiassai, Davide
Gillio, Donatella
Marchesi, Marta
Parolini, Cinzia
Rubio, Luis A.
Sirtori, Cesare R.
Journal name Annals of nutrition and metabolism
Volume number 50
Issue number 6
Start page 528
End page 537
Publisher S. Karger AG
Place of publication Basel, Switzerland
Publication date 2006
ISSN 0250-6807
1421-9697
Keyword(s) casein
lactalbumin
lupinus albus
rat organ weight
protein quality
Summary Background: A protein isolate from white lupin (Lupinus albus; L-ISO) has potential as a novel human food ingredient, but its nutritional effects are unknown.

Methods
: We evaluated protein quality and effects on body composition in rats of isoenergic diets of L-ISO, lactalbumin, or casein with both restricted (10-day) and ad libitum (28-day)intake. The diets were equivalent in protein per se, but supplementation was used to balance essential amino acid levels.

Results: In both studies, the rats consumed similar amounts of each diet, and no effect of diet on the gain:feed ratio was observed--though gain:N ratio and net protein utilization were slightly lower for the L-ISO diet. Lower large intestinal weights after the L-ISO than after the lactalbumin diet were observed in both studies. The L-ISO diet resulted in lowered body fat percentage in the 10-day study but in an elevated level in the 28-day study. Liver composition (DNA, RNA, glycogen, and fat) and plasma levels of some amino acids (His, Thr, Ala, Pro, Tyr, Val and Met) were affected by diet, but no effects on plasma lipid, glucose, or uric acid were observed.

Conclusion
: The L-ISO diet did not affect feed intake and has adequate nutritional quality in rats whilst modifying large intestinal weight in a potentially beneficial manner--suggesting potential for this protein in human nutrition.
Language eng
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2006, S. Karger AG
Persistent URL http://hdl.handle.net/10536/DRO/DU:30009075

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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