Systematic review of randomised controlled trials of sildenafil (Viagra®) in the treatment of male erectile dysfunction.

Burls, Amanda, Gold, Lisa and Clark, Wendy 2001, Systematic review of randomised controlled trials of sildenafil (Viagra®) in the treatment of male erectile dysfunction., British journal of general practice, vol. 51, no. 473, pp. 1004-1012.

Attached Files
Name Description MIMEType Size Downloads

Title Systematic review of randomised controlled trials of sildenafil (Viagra®) in the treatment of male erectile dysfunction.
Author(s) Burls, Amanda
Gold, LisaORCID iD for Gold, Lisa
Clark, Wendy
Journal name British journal of general practice
Volume number 51
Issue number 473
Start page 1004
End page 1012
Publisher Royal College of General Practitioners
Place of publication London, England
Publication date 2001-12
ISSN 0960-1643
Keyword(s) Erectile dysfunction
Randomised controlled trial
Summary Background: Sildenafil (Viagra®), a new oral drug for the treatment of erectile dysfunction, was licensed for use across Europe in 1998. Aim: To examine the effectiveness and safety of sildenafil as an oral treatment for erectile dysfunction. Design of study: Systematic review and meta-analysis.
Setting: All published or unpublished randomised controlled trials comparing sildenafil with a placebo or alternative therapies. Method: Published studies were sought by computerised searches of electronic databases using the keywords ‘sildenafil’ and ‘Viagra’. A hand search was also done of the British Medical Journal, Lancet, Journal of the American
Medical Association, New England Journal of Medicine, British Journal of General Practice, Drug, Inpharma and Scrip. An assessment of quality of all identified studies and data extraction was undertaken independently by two researchers. Results were combined in a meta-analysis where appropriate, using RevMan version 3. Results: Twenty-one trials were identified. All trials showed a statistically significant improvement in erectile or sexual function in patients using sildenafil compared with a placebo. A meta-analysis of 16 trials reporting a global efficacy response showed that men were 3.57 (95% CI = 2.93–4.43) times as likely to have improved erections on sildenafil compared with those on a placebo. The number needed to treat to have one man with improved erections was two. The drug has a relatively safe side-effect profile. Conclusions: Available research shows that sildenafil is an effective treatment for male erectile dysfunction. Many trial participants had some baseline erectile function and it is probable that in clinical practice, where the erectile function tends to be more impaired, the number needed to treat may be higher.
Language eng
Field of Research 110312 Nephrology and Urology
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2001, British Journal of General Practice
Persistent URL

Document type: Journal Article
Collections: Faculty of Health
School of Health and Social Development
Connect to link resolver
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 20 times in TR Web of Science
Scopus Citation Count Cited 25 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 879 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Mon, 13 Oct 2008, 15:51:10 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact