A role for skeletal muscle stearoyl-CoA desaturase 1 in control of thermogenesis

Mainieri, Davide, Summermatter, Serge, Seydoux, Josiane, Montani, Jean-Pierre, Rusconi, Sandro, Russell, Aaron P, Boss, Olivier, Buchala, Antony J and Dulloo, Abdul G 2006, A role for skeletal muscle stearoyl-CoA desaturase 1 in control of thermogenesis, FASEB journal, vol. 20, no. 10, pp. E1157-E1170, doi: 10.1096/fj.06-5934fje.

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Title A role for skeletal muscle stearoyl-CoA desaturase 1 in control of thermogenesis
Author(s) Mainieri, Davide
Summermatter, Serge
Seydoux, Josiane
Montani, Jean-Pierre
Rusconi, Sandro
Russell, Aaron PORCID iD for Russell, Aaron P orcid.org/0000-0002-7323-9501
Boss, Olivier
Buchala, Antony J
Dulloo, Abdul G
Journal name FASEB journal
Volume number 20
Issue number 10
Start page E1157
End page E1170
Total pages 14
Publisher Federation of American Societies for Experimental Biology
Place of publication Bethesda, Md.
Publication date 2006-08
ISSN 0892-6638
Keyword(s) Obesity
Weight cycling
Catch-up growth
Low birth weight
Insulin resistance
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Cell Biology
Summary An enhanced metabolic efficiency for accelerating the recovery of fat mass (or catch-up fat) is a characteristic feature of body weight regulation after weight loss or growth retardation and is the outcome of an "adipose- specific" suppression of thermogenesis, i.e., a feedback control system in which signals from the depleted adipose tissue fat stores exert a suppressive effect on thermogenesis. Using a previously described rat model of semistarvation-refeeding in which catch-up fat results from suppressed thermogenesis per se, we report here that the gene expression of stearoyl-coenzyme A desaturase 1 (SCD1) is elevated in skeletal muscle after 2 wk of semistarvation and remains elevated in parallel to the phase of suppressed thermogenesis favoring catch-up fat during refeeding. These elevations in the SCD1 transcript are skeletal muscle specific and are associated with elevations in microsomal Δ9 desaturase enzyme activity, in the Δ9 desaturation index, and in the relative content of SCD1-derived monounsaturates in several lipid fractions extracted from skeletal muscle. An elevated skeletal muscle SCD1, by desaturating the products of de novo lipogenesis and diverting them away from mitochondrial oxidation, would inhibit substrate cycling between de novo lipogenesis and lipid oxidation, thereby leading to a state of suppressed thermogenesis that regulates the body's fat stores.
Language eng
DOI 10.1096/fj.06-5934fje
Indigenous content off
Field of Research 110104 Medical Biochemistry: Lipids
0601 Biochemistry and Cell Biology
0606 Physiology
1116 Medical Physiology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2006, FASEB
Persistent URL http://hdl.handle.net/10536/DRO/DU:30009112

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