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ß1/ß2/ß3-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting

Jimenez, Maria, Léger, Bertrand, Canola, Kriss, Lehr, Lorenz, Arboit, Patrizia, Seydoux, Josiane, Russell, Aaron, Giacobino, Jean-Paul, Muzzin, Patrick and Prietner, Frédéric 2002, ß1/ß2/ß3-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting, FEBS letters, vol. 530, no. 1-3, pp. 37-40, doi: 10.1016/S0014-5793(02)03387-2.

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Title ß1/ß2/ß3-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting
Author(s) Jimenez, Maria
Léger, Bertrand
Canola, Kriss
Lehr, Lorenz
Arboit, Patrizia
Seydoux, Josiane
Russell, AaronORCID iD for Russell, Aaron orcid.org/0000-0002-7323-9501
Giacobino, Jean-Paul
Muzzin, Patrick
Prietner, Frédéric
Journal name FEBS letters
Volume number 530
Issue number 1-3
Start page 37
End page 40
Publisher Elsevier BV
Place of publication Amsterdam, The Netherlands
Publication date 2002-10-23
ISSN 0014-5793
1873-3468
Keyword(s) β-adrenergic
obesit
uncoupling protein
fasting
thermogenesis
Summary Catecholamines are viewed as major stimulants of diet- and cold-induced thermogenesis and of fasting-induced lipolysis, through the β-adrenoceptors (β1/β2/β3). To test this hypothesis, we generated β1/β2/β3-adrenoceptor triple knockout (TKO) mice and compared them to wild type animals. TKO mice exhibited normophagic obesity and cold-intolerance. Their brown fat had impaired morphology and lacked responses to cold of uncoupling protein-1 expression. In contrast, TKO mice had higher circulating levels of free fatty acids and glycerol at basal and fasted states, suggesting enhanced lipolysis. Hence, β-adrenergic signalling is essential for the resistance to obesity and cold, but not for the lipolytic response to fasting.
Language eng
DOI 10.1016/S0014-5793(02)03387-2
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2002, Federation of European Biochemical Societies
Persistent URL http://hdl.handle.net/10536/DRO/DU:30009122

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