Effect of 2 weeks of endurance training on uncoupling protein3 content in untrained human subjects

Schrauwen, Patrick, Russell, Aaron, Moonen-Kornips, E., Boon, N. and Hesselink, Matthijs 2005, Effect of 2 weeks of endurance training on uncoupling protein3 content in untrained human subjects, Acta physiologica, vol. 183, no. 3, pp. 273-280.

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Title Effect of 2 weeks of endurance training on uncoupling protein3 content in untrained human subjects
Author(s) Schrauwen, Patrick
Russell, Aaron
Moonen-Kornips, E.
Boon, N.
Hesselink, Matthijs
Journal name Acta physiologica
Volume number 183
Issue number 3
Start page 273
End page 280
Publisher Blackwell Publishing Ltd
Place of publication Oxford, England
Publication date 2005-03
ISSN 1748-1708
1748-1716
Keyword(s) exercise
mitochondria
training
uncoupling protein
Summary Aim: The mitochondrial uncoupling protein-3 (UCP3) is able to lower the proton gradient across the inner mitochondrial membrane, thereby uncoupling substrate oxidation from ATP production and dissipating energy as heat. What the effect of endurance training on UCP3 is, is still  controversial. Endurance-trained athletes are characterized by lower levels of UCP3, but longitudinal studies in rodents reported no effect of endurance training on muscular UCP3 levels. Here, we examined the effect of a 2-week training programme on skeletal muscle UCP3 protein content in untrained human subjects, and hypothesized that UCP3 will be reduced after the training programme. Methods: Nine untrained men [age: 23.3±3.2 years; BMI: 22.6±2.6 kg m-2; maximal power output (Wmax): 3.8±0.6 W kg-1 body weight] trained for 2 weeks. Before and at least 72 h after the training period, muscle biopsies were taken for determination of UCP3 protein content. Results: UCP3 protein content tended to be lower after the training programme [95±10 vs. 109±12 arbitrary units (AU), P= 0.08]. Cytochrome c content tended to increase with 33% in response to endurance training (52± 6 vs. 39± 6 AU, P = 0.08). The ratio UCP3 relative to cytochrome c tended to decrease significantly upon endurance training (2.0±0.4 vs. 3.2±0.6 AU, P = 0.01). Conclusion: A short-term (2-week) endurance training programme decreased UCP3 protein levels and significantly reduced the ratio of UCP3 to cytochrome c.
Language eng
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2005, Scandinavian Physiological Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30009124

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