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Mitofusions1/2 and ERRα expression are increased in human skeletal muscle after physical exercise.

Cartoni, Romain, Leger, Bertrand, Hock, M. Benjamin, Praz, Manu, Crettenand, Antoinette, Pich, Sara, Ziltener, Jean-Luc, Luthi, François, Deriaz, Olivier, Zorzano, Antonio, Gobelet, Charles, Kralli, Anastasia and Russell, Aaron 2005, Mitofusions1/2 and ERRα expression are increased in human skeletal muscle after physical exercise., Journal of physiology, vol. 567, no. 1, pp. 349-358.

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Title Mitofusions1/2 and ERRα expression are increased in human skeletal muscle after physical exercise.
Author(s) Cartoni, Romain
Leger, Bertrand
Hock, M. Benjamin
Praz, Manu
Crettenand, Antoinette
Pich, Sara
Ziltener, Jean-Luc
Luthi, François
Deriaz, Olivier
Zorzano, Antonio
Gobelet, Charles
Kralli, Anastasia
Russell, Aaron
Journal name Journal of physiology
Volume number 567
Issue number 1
Start page 349
End page 358
Publisher Cambridge University Press
Place of publication London, England
Publication date 2005
ISSN 0022-3751
1469-7793
Summary Mitochondrial impairment is hypothesized to contribute to the pathogenesis of insulin resistance. Mitofusin (Mfn) proteins regulate the biogenesis and maintenance of the mitochondrial network, and when inactivated, cause a failure in the mitochondrial architecture and decreases in oxidative capacity and glucose oxidation. Exercise increases muscle mitochondrial content, size, oxidative capacity and aerobic glucose oxidation. To address if Mfn proteins are implicated in these exercise-induced responses, we measured Mfn1 and Mfn2 mRNA levels, pre-, post-, 2 and 24 h post-exercise. Additionally, we measured the expression levels of transcriptional regulators that control mitochondrial biogenesis and functions, including PGC-1α, NRF-1, NRF-2 and the recently implicated ERRα. We show that Mfn1, Mfn2, NRF-2 and COX IV mRNA were increased 24 h post-exercise, while PGC-1α and ERRα mRNA increased 2 h post-exercise. Finally, using in vitro cellular assays, we demonstrate that Mfn2 gene expression is driven by a PGC-1α programme dependent on ERRα. The PGC-1α/ERRα-mediated induction of Mfn2 suggests a role of these two factors in mitochondrial fusion. Our results provide evidence that PGC-1α not only mediates the increased expression of oxidative phosphorylation genes but also mediates alterations in mitochondrial architecture in response to aerobic exercise in humans.
Language eng
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2005, The Physiological Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30009131

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Created: Mon, 13 Oct 2008, 15:52:01 EST