Safety and efficacy of routine postoperative ibuprofen for pain and disability related to ectopic bone formation after hip replacement surgery (HIPAID): a randomised control trial

Safety and efficacy of routine postoperative ibuprofen for pain and disability related to ectopic bone formation after hip replacement surgery (HIPAID): a randomised control trial

Fransen, Marlene, Andreson, Craig, Douglas, Jan, McMahon, Stephen, Neal, Bruce, Norton, Robyn, Woodward, Mark, Cameron, Ian D., Crawford, Ross, Lo, Sing Kai, Tregonning, Garnet and Windolf, Margaret 2006, Safety and efficacy of routine postoperative ibuprofen for pain and disability related to ectopic bone formation after hip replacement surgery (HIPAID): a randomised control trial, BMJ, vol. 333, no. 7567, pp. 519-524.

Attached Files (Some files may be inaccessible until you login with your Deakin Research Online credentials)
Name			Description	MIMEType		Size	Downloads
lo-safetyandefficacy-2006.pdf			Published version		application/pdf	301.50KB	93

Title	Safety and efficacy of routine postoperative ibuprofen for pain and disability related to ectopic bone formation after hip replacement surgery (HIPAID): a randomised control trial
Author(s)	Fransen, Marlene Andreson, Craig Douglas, Jan McMahon, Stephen Neal, Bruce Norton, Robyn Woodward, Mark Cameron, Ian D. Crawford, Ross Lo, Sing Kai Tregonning, Garnet Windolf, Margaret
Journal name	BMJ
Volume number	333
Issue number	7567
Start page	519
End page	524
Publisher	B M J Publishing
Place of publication	London, England
Publication date	2006-09-09
ISSN	0959-535x
Keyword(s)	ibuprofen nonsteroid antiinflammatory agent total hip prosthesis replacement hip
Summary	Objectives To determine the benefits and risks of a non-steroidal anti-inflammatory drug (NSAID) as prophylaxis for ectopic bone formation in patients undergoing total hip replacement (or revision) surgery. Design Double blind randomised placebo controlled clinical trial, stratified by treatment site and surgery (primary or revision). Setting 20 orthopaedic surgery centres in Australia and New Zealand. Participants 902 patients undergoing elective primary or revision total hip replacement surgery. Intervention 14 days' treatment with ibuprofen (1200 mg daily) or matching placebo started within 24 hours of surgery. Main outcome measures Changes in self reported hip pain and physical function 6 to 12 months after surgery (Western Ontario and McMaster University Arthritis index). Results There were no significant differences between the groups for improvements in hip pain (mean difference -0.1, 95% confidence interval -0.4 to 0.2, P = 0.6) or physical function (-0.1, -0.4 to 0.2, P = 0.5), despite a decreased risk of ectopic bone formation (relative risk 0.69, 0.56 to 0.83) associated with ibuprofen. There was a significantly increased risk of major bleeding complications in the ibuprofen group during the admission period (2.09, 1.00 to 4.39). Conclusions These data do not support the use of routine prophylaxis with NSAIDs in patients undergoing total hip replacement surgery. Trial registration NCT00145730.
Language	eng
Field of Research	111502 Clinical Pharmacology and Therapeutics
Socio Economic Objective	860899 Human Pharmaceutical Products not elsewhere classified
HERDC Research category	C1 Refereed article in a scholarly journal
ERA Research output type	C Journal article
Copyright notice	©2006, BMJ Publishing Group Ltd
Persistent URL	http://hdl.handle.net/10536/DRO/DU:30009134

Document type:	Journal Article
Collections:	School of Health and Social Development Open Access Collection

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.

Citation counts:	Cited 21 times in TR Web of Science Cited 33 times in Scopus
Access Statistics:	472 Abstract Views, 93 File Downloads - Detailed Statistics
Created:	Mon, 13 Oct 2008, 15:52:06 EST

Deakin Research Online

Safety and efficacy of routine postoperative ibuprofen for pain and disability related to ectopic bone formation after hip replacement surgery (HIPAID): a randomised control trial

Study

Research

Access Deakin

On campus

Connect