Analysis of cardioprotective effects using purified Saliva miltiorrhiza extract on isolated rat hearts

Chang, Piek Ngoh, Mao, Jian Chun, Huang, Shan Hong, Ning, Li, Wang, Zhong Jing, On, Todd, Duan, Wei and Zhu, Yi Zhun 2006, Analysis of cardioprotective effects using purified Saliva miltiorrhiza extract on isolated rat hearts, Journal of Pharmacological Sciences, vol. 101, pp. 245-249.

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Title Analysis of cardioprotective effects using purified Saliva miltiorrhiza extract on isolated rat hearts
Formatted title Analysis of cardioprotective effects using purified Saliva miltiorrhiza extract on isolated rat hearts
Author(s) Chang, Piek Ngoh
Mao, Jian Chun
Huang, Shan Hong
Ning, Li
Wang, Zhong Jing
On, Todd
Duan, Wei
Zhu, Yi Zhun
Journal name Journal of Pharmacological Sciences
Volume number 101
Start page 245
End page 249
Publisher Nihon Yakuri Gakkai Henshuubu
Place of publication Japan
Publication date 2006
ISSN 1347-8613
Keyword(s) purified Salvia miltiorrhiza extract
cardioprotective effect
myocardial ischemia/ reperfusion
isolated rat heart
Summary The purpose of the current study is to evaluate the cardioprotective effects of purified Salvia miltiorrhiza extract (PSME) on myocardial ischemia/reperfusion injury in isolated rat hearts. Hearts were excised and perfused at constant flow (7 – 9 ml · min−1) via the aorta. Non-recirculating perfusion with Krebs-Henseleit (KH) solution was maintained at 37°C and continuously gassed with 95% O2 and 5% CO2. KH solution with or without PSME (100 mg per liter solution) was used after 30-min zero-flow ischemia for the PSME and control group, respectively. Left ventricular (LV) developed pressure; its derivatives, diastolic pressure, and so on were continuously recorded via a pressure transducer attached to a polyvinylchloride balloon that was placed in the left ventricle through an incision in the left atrium. PSME treated hearts showed significant postischemic contractile function recovery (developed pressure recovered to 44.2 ± 4.9% versus 17.1 ± 5.7%, P<0.05; maximum contraction recovered to 57.2 ± 5.9% versus 15.1 ± 6.3%, P<0.001; maximum relaxation restored to 69.3 ± 7.3% versus 15.4 ± 6.3%, P<0.001 in the PSME and control group, respectively). Significant elevation in end-diastolic pressure, which indicated LV stiffening in PSME hearts might have resulted from the excess high dose of PSME used. Further study will be conducted on the potential therapeutic value with lower dose of PSME on prevention of ischemic heart disease.
Language eng
Field of Research 110201 Cardiology (incl Cardiovascular Diseases)
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2006, The Japanese Pharmacological Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30009142

Document type: Journal Article
Collection: School of Medicine
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