Effects of purified herbal extract of Saliva miltiorrhiza on ischemic rat myocardium after acute myocardial infarction

Sun, Jian, Huang, Shan Hong, Tan, Benny, Whiteman, Matt, Zhu, Yi Chun, Wu, Ya Jun, Ng, Yeekong, Duan, Wei and Zhu, Yi Zhun 2005, Effects of purified herbal extract of Saliva miltiorrhiza on ischemic rat myocardium after acute myocardial infarction, Life sciences, vol. 76, no. 24, pp. 2849-2860.

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Title Effects of purified herbal extract of Saliva miltiorrhiza on ischemic rat myocardium after acute myocardial infarction
Formatted title Effects of purified herbal extract of Saliva miltiorrhiza on ischemic rat myocardium after acute myocardial infarction
Author(s) Sun, Jian
Huang, Shan Hong
Tan, Benny
Whiteman, Matt
Zhu, Yi Chun
Wu, Ya Jun
Ng, Yeekong
Duan, Wei
Zhu, Yi Zhun
Journal name Life sciences
Volume number 76
Issue number 24
Start page 2849
End page 2860
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2005-04-29
ISSN 0024-3205
Keyword(s) purified Salvia miltiorrhiza extract (PSME)
myocardial infarction
Salvia miltiorrhiza
antioxidant
infarct size
Ramipril
Summary In the current study, we compared purified Salvia miltiorrhiza extract (PSME) with Angiotensin-converting enzyme inhibitor, Ramipril, in in vitro experiments and also in vivo using animal model of myocardial infarction. PSME was found to have a significantly higher trolox equivalent antioxidant capacity which indicated a great capacity for scavenging free radicals. PSME could also prevent pyrogallo red bleaching and DNA damage.

After 2 weeks treatment with PSME or Ramipril, survival rates of rats with experimental myocardial infarction were marginally increased (68.2% and 71.4%) compared with saline (61.5%). The ratios of infarct size to left ventricular size in both PSME-and Ramipril-treated rats were significantly less than that in the saline-treated group. Activity of cardiac antioxidant enzyme superoxide dismutase (SOD) was significant higher while level of Thiobarbituric acid-reactive substances (TBARs) was lower in the PSME treated group. Purified and standardized Chinese herb could provide an alternative regimen for the prevention of ischemic heart disease.
Language eng
Field of Research 111502 Clinical Pharmacology and Therapeutics
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2005, Elsevier Inc.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30009149

Document type: Journal Article
Collection: School of Medicine
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