Genetic polymorphisms of cytochrome P450 2B6 gene in Han Chinese

Guan, Su, Huang, Min, Chan, Eli, Chen, Xiao, Duan, Wei and Zhou, Shu-Feng 2006, Genetic polymorphisms of cytochrome P450 2B6 gene in Han Chinese, European journal of pharmaceutical sciences, vol. 29, no. 1, pp. 14-21.

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Title Genetic polymorphisms of cytochrome P450 2B6 gene in Han Chinese
Author(s) Guan, Su
Huang, Min
Chan, Eli
Chen, Xiao
Duan, Wei
Zhou, Shu-Feng
Journal name European journal of pharmaceutical sciences
Volume number 29
Issue number 1
Start page 14
End page 21
Publisher Elsevier B.V.
Place of publication Amsterdam, The Netherlands
Publication date 2006-09
ISSN 0928-0987
Keyword(s) CYP2B6
Chinese
single nucleotide polymorphism
ethnicity
Summary Cytochrome P450 (CYP2B6) is an important enzyme that metabolizes more than eight compounds and about 3.0% of therapeutic drugs. The genetic polymorphisms of CYP2B6 have earlier been studied in Caucasian, Japanese and Korean, but the data are lacking for Han Chinese. The aim of this study was to investigate the frequencies of allelic variants of CYP2B6 in healthy Han Chinese and compare with those in other ethnic groups reported in the literature. Polymerase chain reaction (PCR)–restriction fragment length polymorphism (RFLP) method was used to test the five common non-synonymous single nucleotide polymorphisms (SNPs) of CYP2B6 gene, namely, 64C > T, 516G > T, 777C > A, 785A > G and 1459C > T in unrelated healthy Han Chinese (n = 193). The study demonstrated that the frequencies of 64C > T, 516G > T, 777C > A, 785A > G and 1459C > T SNPs in Han Chinese were 0.03, 0.21, 0, 0.28 and 0.003, respectively. The frequencies of all five SNPs tested in female were higher than those in male, but the statistical difference was insignificant (P > 0.05). Compared to the data reported in the literature, the frequencies of common CYP2B6 allelic variants in Chinese are similar to those of other Asian populations including Japanese and Korean, but markedly different from those in Caucasians. These results indicate the presence of marked ethnic difference in CYP2B6 SNP frequencies between Chinese and Caucasian. Further studies are required to explore the impact of these SNPs of CYP2B6 gene on the clinical response (efficacy and toxicity) to drugs that are substrates for CYP2B6 in patients.
Language eng
Field of Research 110311 Medical Genetics (excl Cancer Genetics)
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2006, Elsevier B.V.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30009153

Document type: Journal Article
Collection: School of Medicine
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