A comparison study of cerebral protection using Ginkgo biloba extract and Losartan on stroked rats

Loh, K., Low, L., Wong, W., Zhou, S., Huang, S., Silva, R., Duan, Wei, Chou, W. and Zhu, Y. 2006, A comparison study of cerebral protection using Ginkgo biloba extract and Losartan on stroked rats, Neuroscienceletters, vol. 398, no. 1-2, pp. 28-33.

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Title A comparison study of cerebral protection using Ginkgo biloba extract and Losartan on stroked rats
Formatted title Comparison study of cerebral protection using Ginkgo biloba extract and Losartan on stroked rats
Author(s) Loh, K.
Low, L.
Wong, W.
Zhou, S.
Huang, S.
Silva, R.
Duan, Wei
Chou, W.
Zhu, Y.
Journal name Neuroscienceletters
Volume number 398
Issue number 1-2
Start page 28
End page 33
Publisher Elsvier Ireland Ltd
Place of publication Limerick, Ireland
Publication date 2006-05
ISSN 0304-3940
Keyword(s) Ginkgo biloba extract
losartan
cerebral protection
stroke
rats
Summary It has been well documented that oxidative stress is involved in stroke. Currently, many neuroprotective strategies have been targeted at molecules that are able to act as an oxidant to intervene with free-radical mediated apoptosis in the ischemic penumbra. In particular, natural products which contain antioxidant properties have undoubtedly efficacious for stroke treatment. In the current study, therapeutic effects of Ginkgo biloba extract (EGb) against cerebral protection in Wistar rats underwent middle cerebral artery occlusion (MCAO) was evaluated. A comparison study was conducted by using Losartan, an antihypertensive drug. Gene expression levels of pro-apoptotic genes (AT2 receptor, Fas, Bax and Bcl-xS) have shown to have significant reduction by EGb- and Losartan-treated groups as compared to vehicle group. Significant reduction of immunoreactivity of protein production of these genes, together with least nuclear green fluorescence observed in TUNEL, EGb, as an antioxidant drug, is concluded to have potent and promising therapeutic effect for stroke treatment.
Language eng
Field of Research 111502 Clinical Pharmacology and Therapeutics
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2005, Elsvier Ireland Ltd
Persistent URL http://hdl.handle.net/10536/DRO/DU:30009170

Document type: Journal Article
Collection: School of Medicine
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