VNTR polymorphism of the insulin gene and childhood overweight in a general population

Heude, Barbara, Dubois, Severine, Charles, Marie-Aline, Deweirder, Marianne, Dina, Christian, Borys, Jean-Michel, Ducimetiere, Pierre and Froguel, Philippe 2004, VNTR polymorphism of the insulin gene and childhood overweight in a general population, Obesity, vol. 12, no. 3, pp. 499-504, doi: 10.1038/oby.2004.56.

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Title VNTR polymorphism of the insulin gene and childhood overweight in a general population
Author(s) Heude, Barbara
Dubois, Severine
Charles, Marie-Aline
Deweirder, Marianne
Dina, Christian
Borys, Jean-Michel
Ducimetiere, Pierre
Froguel, Philippe
Journal name Obesity
Volume number 12
Issue number 3
Start page 499
End page 504
Publisher North American Association for the Study of Obesity
Place of publication Silver Spring, Md.
Publication date 2004-03
ISSN 1930-7381
Keyword(s) childhood overweight
genetic epidemiology
common variant
Summary Objective: The VNTR polymorphism 5' of the insulin gene has been related to obesity in a previous study on children with early onset of severe obesity. Our purpose was to analyze the association between this polymorphism and adiposity variability in an unselected population of children and adolescents in northern France.

Research Methods and Procedures: In 293 nuclear families from the Fleurbaix Laventie Ville Santé study, we genotyped the INS VNTR polymorphism in 431 children and adolescents (8 to 18 years of age) and their parents. Overweight was defined according to the international definition in both children and adults. A transmission disequilibrium test in families with an overweight offspring was performed. The prevalence of overweight was compared according to genotype. The effect of the genotype on BMI and waist circumference was tested with a linear regression model, adjusting for age, gender, and Tanner stage.

Results: There was an undertransmission of class III alleles from heterozygous parents to their overweight offspring (p < 0.002). Overweight was associated with class I alleles in children and adolescents (12% I/I, I/III vs. 3% III/III; p < 0.08). Those with a class III/III genotype had a 1 kg/m2 lower mean BMI (p = 0.04) and 3 cm lower waist circumference (p = 0.02) than those bearing one or two class I alleles. No association of adiposity or obesity with class I alleles was found in parents.

Discussion: INS VNTR polymorphism seems to contribute to differences in adiposity level in the general population of children and adolescents.
Language eng
DOI 10.1038/oby.2004.56
Field of Research 060412 Quantitative Genetics (incl Disease and Trait Mapping Genetics)
HERDC Research category C1.1 Refereed article in a scholarly journal
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Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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