Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type 1 and type 2 cytokine-mediated inflammatory reactions

Hoffmann, Karl, McCarty, Thomas, Segal, David, Chiaramonte, Monica, Hesse, Matthias and Davis, Eric 2001, Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type 1 and type 2 cytokine-mediated inflammatory reactions, The FASEB journal : official publication of the Federation of American Societies for experimental biology, vol. 15, no. 13, pp. 2545-2547.

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Title Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type 1 and type 2 cytokine-mediated inflammatory reactions
Formatted title Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type 1 and type 2 cytokine-mediated inflammatory reactions1
Author(s) Hoffmann, Karl
McCarty, Thomas
Segal, David
Chiaramonte, Monica
Hesse, Matthias
Davis, Eric
Journal name The FASEB journal : official publication of the Federation of American Societies for experimental biology
Volume number 15
Issue number 13
Start page 2545
End page 2547
Publisher Federation of American Societies for Experimental Biology
Place of publication Bethesda, Md.
Publication date 2001-11
ISSN 0892-6638
1530-6860
Keyword(s) schistosomiasis
Th1/Th2
liver
mice
fibrosis
Summary Development of polarized immune responses controls resistance and susceptibility to many microorganisms. However, studies of several infectious, allergic, and autoimmune diseases have shown that chronic type-1 and type-2 cytokine responses can also cause significant morbidity and mortality if left unchecked. We used mouse cDNA microarrays to molecularly phenotype the gene expression patterns that characterize two disparate but equally lethal forms of liver pathology that develop in Schistosoma mansoni infected mice polarized for type-1 and type-2 cytokine responses. Hierarchical clustering analysis identified at least three groups of genes associated with a polarized type-2 response and two linked with an extreme type-1 cytokine phenotype. Predictions about liver fibrosis,  apoptosis, and granulocyte recruitment and activation generated by the microarray studies were confirmed later by traditional biological assays. The data show that cDNA microarrays are useful not only for determining  coordinated gene expression profiles but are also highly effective for molecularly “fingerprinting” diseased tissues. Moreover, they illustrate the potential of genome-wide approaches for generating comprehensive views on the molecular and biochemical mechanisms regulating infectious  disease pathogenesis.
Language eng
Field of Research 060405 Gene Expression (incl Microarray and other genome-wide approaches)
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2001, FASEB
Persistent URL http://hdl.handle.net/10536/DRO/DU:30009236

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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