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Lipids and FA analysis of canine prostate tissue

Attar-Bashi, Nadia M., Orzeszko, Karyn, Slocombe, Ronald F. and Sinclair, Andrew 2003, Lipids and FA analysis of canine prostate tissue, Lipids, vol. 38, no. 6, pp. 665-668.

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Title Lipids and FA analysis of canine prostate tissue
Author(s) Attar-Bashi, Nadia M.
Orzeszko, Karyn
Slocombe, Ronald F.
Sinclair, Andrew
Journal name Lipids
Volume number 38
Issue number 6
Start page 665
End page 668
Publisher Springer Berlin
Place of publication Berlin, Germany
Publication date 2003-06
ISSN 0024-4201
1558-9307
Summary It is widely reported that an association exists between dietary fat intake and the incidence of prostate cancer in humans. To study this association, there is a need for an animal model where prostate carcinogenesis occurs spontaneously. The canine prostate is considered a suitable experimental model for prostate cancer in humans since it is morphologically similar to the human prostate and both humans and dogs have a predisposition to benign and malignant prostate disease. In this study, the FA and lipids profiles of the normal canine prostate tissue from nine dogs were examined. The total lipid content of the canine prostate tissue was 1.7±0.5% (wet weight). The lipid composition analysis using TLC-FID showed that the two major lipid classes were phospholipids and TAG. Total FA, phospholipid, and TAG FA analysis showed that the major FA were palmitic acid (16∶0), stearic acid (18∶0), oleic acid (18∶1), linoleic acid (18∶2n−6), and arachidonic acid (20∶4n−6), The n−3 FA were present at <3% of total FA and included α-linolenic acid (18∶3n−3) (in total and TAG tissue FA), EPA (20∶5n−3) (not in TAG), and DHA (22∶6n−3) (not in TAG). The n−3/n−6 ratio was 1∶11, 1∶13, and 1∶8 in total, phospholipid, and TAG FA, respectively. This study shows the canine prostate has a low level of n−3 FA and a low n−3/n−6 ratio. This is perhaps due to low n−3 content of the diet of the dogs. FA analysis of dogfoods available in Australia showed that the n−3 content in both supermarket and premium bran dogfoods was <3% (wet weight), and the n−3/n−6 ratio was low.

Notes SpringerLink Date Wednesday, November 15, 2006
Language eng
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2003 by AOCS Press
Persistent URL http://hdl.handle.net/10536/DRO/DU:30009289

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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Created: Mon, 13 Oct 2008, 15:56:36 EST